International
Moderna, Merck see positive results from skin cancer vaccine
| By AFP |
The Moderna and Merck drug makers on Tuesday announced positive results from a trial in which messenger RNA technology was used for the first time to make personalized vaccines for skin cancer patients.
The mRNA technology proved vital in the development of vaccines against Covid-19, and scientists have long believed it could help fight other viruses and diseases like cancer.
In a preliminary trial, 150 people who had had their melanoma tumor surgically removed were given up to nine doses of the experimental vaccine alongside the skin cancer treatment Keytruda.
The study showed a 44 percent reduction in risk of death or relapse compared to patients who were only treated with Keytruda, an immunotherapy medicine.
“Today’s results are highly encouraging for the field of cancer treatment,” Moderna’s Chief Executive Officer Stephane Bancel, said in a statement.
“mRNA has been transformative for COVID-19, and now, for the first time ever, we have demonstrated the potential for mRNA to have an impact on outcomes in a randomized clinical trial in melanoma.”
Moderna and Merck, known as MSD outside of North America, will soon publish the full results of the study, the results of which have not yet been peer-reviewed. The companies will also launch a Phase 3 trial in 2023, which involves a larger number of patients.
Messenger RNA is a molecule within cells that carries instructions to form proteins. Scientists can design them to make a particular protein in the body that can help fight viruses and other illnesses.
Moderna and drugmaker Pfizer-BioNTech were the first to use the technology to create the mRNA vaccines used to fight Covid-19.
The melanoma vaccine is tailor-made to “prime the immune system so that a patient can generate a tailored antitumor response specific to their tumor mutation signature,” said Moderna’s statement.
Melanoma is the worst form of skin cancer, and nearly 325,000 new cases were diagnosed in 2020. Some 8,000 people are expected to die from melanoma in 2022, said the statement.
Moderna and Merck agreed in October to jointly develop the personalized skin cancer vaccine, for which they will share costs and profits.
International
Pope Francis meets former Gaza hostages
Pope Francis met on Thursday at the Vatican with 16 Israelis who had been held hostage in Gaza for months by the Islamist group Hamas, according to the official Vatican news website.
The group consisted of ten women, four men, and two children, as reported by the same source. Several of the former hostages showed the Argentine pontiff banners or photos of their loved ones who remain in captivity.
Francis had previously met with the families of hostages in April this year and November 2023, but this was the first time he had met with individuals who had personally endured captivity.
Since the conflict between Israel and Hamas began, the pope has repeatedly called for the immediate release of Israeli hostages, while also condemning the suffering of the Palestinian population.
The war erupted on October 7, 2023, when Islamist militants attacked southern Israel, killing 1,206 people, mostly civilians, and kidnapping 251, according to an AFP tally based on official Israeli figures that include hostages who died in captivity.
Of the kidnapped, 97 are still being held in Gaza, but the Israeli military estimates that 34 of them have died.
The military offensive launched by Israel in response has killed at least 43,736 people in the Gaza Strip, mostly civilians, according to data from the Ministry of Health in the Hamas-governed territory.
International
Israeli airstrikes on Damascus kill 15 and injure 16, including women and children
Israeli forces carried out airstrikes on residential buildings in the Syrian capital, Damascus, and its surroundings on Thursday, resulting in at least 15 deaths and 16 injuries, according to Syria’s Ministry of Defense and state television.
The ministry stated that around 3:20 p.m. local time (12:20 GMT), the Israeli military launched an aerial attack from the direction of the occupied Golan Heights, targeting several residential buildings in the Mazzeh neighborhood in western Damascus and the Qudsaya suburb to the northwest of the capital.
The airstrikes “resulted in the death of 15 people and injuries to 16 others, including women and children,” based on initial estimates, in addition to significant damage to private property and civilian buildings, the ministry added.
Meanwhile, state television reported Israeli airstrikes on three buildings in Mazzeh and another on a building in an educational complex located in a residential area of Qudsaya.
Following the strikes, loud explosions were heard throughout the city, and thick plumes of smoke could be seen rising from the targeted locations. Ambulances and emergency services rushed to the scene to attend to the victims.
International
Drug trafficker dies after boat collision with Guardia Civil Vessel in Sanlúca
Three people were on the boat that collided with a Guardia Civil vessel around midnight at the mouth of the Guadalquivir River in Sanlúcar de Barrameda, near the Andalusian city of Cádiz, a spokesperson for the Civil Guard reported.
Two officers sustained “contusions,” the spokesperson explained.
The drug traffickers managed to bring the boat to shore, where one of them was “abandoned” severely injured. The other two fled.
The Civil Guard officers attempted to resuscitate the victim before transporting him to Sanlúcar de Barrameda, but he ultimately died early in the morning.
The other two suspects took advantage of the officers’ absence while they were taking the victim and returned to set their boat on fire.
The collision occurred very close to the site of another accident on September 1, where a drug trafficker died following a Guardia Civil pursuit.
The suspects’ boat traveled “400 meters” before crashing head-on and “at full speed” into the riverbank, where a hundred bundles of hashish were found.
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