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AstraZeneca hits snag in Covid drug development

AFP/Editor

Pharmaceutical giant AstraZeneca on Tuesday revealed it had hit a setback in trials of a treatment for Covid-19 symptoms.

The drug, made from a combination of two antibodies, failed its main goal to treat symptoms in exposed patients, the company said in a statement.

The treatment has been undergoing phase 3 or final-stage clinical trials to assess its safety and efficacy.

AstraZeneca said that 1,121 unvaccinated adults had been exposed to an infected person as part of the trial.

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Treatment AZD7442 reduced the risk of developing symptoms by only 33 percent — which was “not statistically significant”, it added.

The company is nevertheless continuing trials to assess whether the drug can prevent Covid or treat more severe symptoms.

The US government has funded the development of AZD7442 and has agreements to receive 700,000 doses.

Meanwhile, AstraZeneca’s Covid vaccine, which was developed with the University of Oxford, faced fresh safety doubts.

The jab has been suspended in several European countries over reports of rare blood clots.

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A top official in the European Medicines Agency was on Sunday reported as having suggested that it might be worth abandoning AstraZeneca’s vaccine if alternatives were available.

But the EMA said the body’s head of vaccine strategy, Marco Cavaleri, had been misrepresented, and that he believed its benefits outweigh its risks.

“The decision on its use in different populations and ages is the prerogative of the EU Member States, based on specific factors such as virus circulation and vaccine availability,” a spokeswoman said.

A study from British health authorities published on Monday found that two doses of AstraZeneca/Oxford or rival Pfizer/BioNTech vaccines stopped the need for in-patient treatment in more than 90 percent of cases of the Delta variant.

The UK government on Monday announced a four-week delay to the full lifting of coronavirus restrictions in England due to a surge in infections caused by Delta, which first appeared in India.

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María Corina Machado kidnapped and forced to record videos before being released, says opposition

The Venezuela Command, the campaign team of opposition leader Edmundo González Urrutia, denounced the “kidnapping” and subsequent release of political leader María Corina Machado after she led a protest in Caracas on the eve of the Venezuelan presidential inauguration.

In a post on X, the opposition team stated that the former lawmaker was “intercepted and knocked off the motorcycle she was traveling on” after leading a rally in the Chacao area of the Venezuelan capital.

“Gunshots were fired during the incident. She was forcibly detained. During her kidnapping, she was forced to record several videos, and then she was released,” the statement added, which was made public nearly two hours after Machado’s party, Vente Venezuela, reported that she had been “violently intercepted.”

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International

Governor Jenniffer González expresses solidarity with Venezuela’s struggling opposition

Puerto Rico’s Governor Jenniffer González expressed her sorrow over Venezuela’s political crisis on Thursday and voiced her support for Venezuelan opposition leader Edmundo González Urrutia, just one day before President Nicolás Maduro is set to take office following the controversial July elections.

“I think it is sad that the Venezuelan people have to suffer the consequences of a dictator who came to power by deceiving the people. I recognize Edmundo González for his leadership,” the governor stated during a press conference, coinciding with a day of protests by Venezuela’s opposition.

“The Venezuelan community has my full support, and, as we have done in the past, we will maintain that line of communication with whatever we can collaborate on,” assured the Puerto Rican head of government.

González Urrutia is currently in the Dominican Republic, the last announced stop on his American tour, where he was accompanied by Dominican President Luis Abinader and former Latin American presidents from the Spain and Americas Democratic Initiative (Grupo Idea).

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International

Hundreds of venezuelan protesters demand ‘democratic change’ in Rome

Dozens of Venezuelans demonstrated in central Rome on Thursday to show their support for opposition leader Edmundo González Urrutia and demand a “democratic change,” on the eve of the presidential inauguration that has deeply divided the country.

The protest took place in the Roman square of Largo Argentina and gathered several members of the Venezuelan diaspora and refugees, who sang their national anthem and displayed signs with the slogan “Glory to the brave people.”

Around 150 participants were present, according to one of the coordinators of the protest, Celeste Puerta from the ‘Aiuto Venezuela’ Civic Movement, who spoke to EFE.

Similar actions have been organized in other Italian cities, including Bologna, Florence, and Milan in the north.

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