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Treatment improves cognition in Down Syndrome patients

AFP

A new hormone treatment improved the cognitive function of six men with Down Syndrome by 10-30 percent, scientists said Thursday, adding the “promising” results may raise hopes of improving patients’ quality of life.

However the scientists emphasised the small study did not point towards a cure for the cognitive disorders of people with Down Syndrome and that far more research is needed.

“The experiment is very satisfactory, even if we remain cautious,” said Nelly Pitteloud of Switzerland’s Lausanne University Hospital and co-author of a new study in the journal Science.

Down Syndrome is the most common genetic form of intellectual disability, occurring in around one in 1,000 people, according to the World Health Organization.

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Yet previous research has failed to significantly improve cognition when applied to people with the condition, which is why the latest findings are “particularly important”, the study said.

Recent discoveries have suggested that how the gonadotropin-releasing hormone (GnRH) is produced in the brain can affect cognitive functioning such as memory, language and learning.

GnRH hormones regulate how much testosterone and estrogen is produced and increased levels of it help spur puberty.

“We wondered if this hormone could play any role in establishing the symptoms of people with Down Syndrome,” said Vincent Prevot, study co-author and head of neuroscience research at France’s INSERM institute. 

– Mice research –

The team first established that five strands of microRNA regulating the production of GnRH were dysfunctional in mice specifically engineered for Down Syndrome research.

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They then demonstrated that cognitive deficiencies — as well as loss of smell, a common symptom of Down Syndrome — were linked to dysfunctioning GnRH secretion in the mice.

The team then gave the mice a GnRH medication used to treat low testosterone and delayed puberty in humans, finding that it restored some cognitive function and sense of smell.

A pilot study was conducted in Switzerland involving seven men with Down Syndrome aged 20 to 50.

They each received the treatment through  their arm every two hours over a period of six months, with the drug delivered in pulses to mimic the hormone’s frequency in people without Down Syndrome.

Cognition and smell tests were carried out during the treatment, as were MRI scans.

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Six of the seven men showed improvement in cognition with no significant side effects — however none showed a change in their sense of smell.

“We have seen an improvement of between 10-30 percent in cognitive functions, in particular with visuospatial function, three-dimensional representation, understanding of instructions as well as attention,” Pitteloud said.

The patients were asked to draw a simple 3D bed at several stages throughout the therapy. Many struggled at the beginning but by the end the efforts were noticeably better.

– ‘Improve quality of life’ –

The authors acknowledged some limitations of the study, including its size and that the choice of patients was “pushed by their parents”.

“The clinical trial only focused on seven male patients — we still have a lot of work to do to prove the effectiveness of GnRH treatment for Down Syndrome,” Pitteloud said.

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A larger study involving a placebo and 50 to 60 patients, a third of them women, is expected to begin in the coming months.

“We are not going to cure the cognitive disorders of people with Down Syndrome, but the improvement seen in our results already seems fundamental enough to hope to improve their quality of life,” Pitteloud said.

Fabian Fernandez, an expert in cognition and Down Syndrome at the University of Arizona who was not involved in the research, hailed the “tour de force study”.

He told AFP that while it is “difficult to envision” how such an intensive treatment could be used for young people, it might be better suited to delay the Alzheimer’s disease-related dementia suffered by many adults with Down Syndrome.

It was also difficult to predict how such an improvement could impact the lives of people with the condition, he said.

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“For some, it could be significant, however, as it would enable them to be more independent with daily living activities such as maintaining and enjoying hobbies, finding belongings, using appliances in the home, and travelling alone.”

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International

A magnitude 6 earthquake shakes the province of Esmeraldas in Ecuador, bordering Colombia

A magnitude 6 earthquake was recorded this Friday in the coastal province of Esmeraldas, bordering Colombia, causing damage to several infrastructures and leaving, so far, 20 people injured.

According to the Geophysical Institute of the National Polytechnic School, the earthquake occurred at 06:44 local time (11:44 GMT) at 1.03 degrees south latitude and 79.69 degrees west longitude.

According to the source, the tremor occurred at a depth of 30 kilometers and 9.31 kilometers from Esmeraldas, capital of the homonymous province.

According to the National Secretariat of Risk Management (SNGR), the affected people had head injuries and bruises.

While the SNGR continues with the verification of affectations, it indicated that 80% of the electricity service and 80% of the telecommunications that were affected, are gradually restored.

Among the affected public buildings are the ECU 911 due to a fall of masonry; the Vargas Torres University, which has cracks; the Los Militares building where the front collapsed and the Prefecture building, among others.

The SNGR reported that the earthquake was felt with strong intensity in seven municipalities of the province of Esmeraldas and moderately in the provinces of Guayas and Manabí, while mildly in Carchi, Cotopaxi, Imbabura, Los Ríos, Pichincha, Santo Domingo de los Tsáchilas and Tungurahua.

About twenty minutes after the earthquake in Esmeraldas, one of magnitude 4.1 was reported in the coastal province of Guayas, located in the southeast of the country, without damage or victims having been reported so far.

The President of Ecuador, Daniel Noboa, ordered the displacement of all his ministers to Esmeraldas, in order to coordinate actions after the magnitude 6 earthquake recorded this Friday.

“I have arranged for the immediate deployment of all ministers in the province of Esmeraldas to coordinate the installation of shelters, delivery of humanitarian aid kits and assistance in everything our people need,” Noboa wrote on his social network account X.

The province of Esmeraldas was one of the most affected by the 7.8 magnitude earthquake recorded on April 16, 2016, which left more than 670 dead, thousands affected, as well as millions of material losses.

This earthquake also hit the province of Manabí, located, like Esmeraldas, on the coast of the Andean country, but also affected other areas and was felt strongly, even in the Ecuadorian capital.

Ecuador is located in the Pacific Ring of Fire or Belt, which concentrates some of the most important subduction areas (sinking of tectonic plates) in the world and is the scene of strong seismic activity.

In addition to Ecuador, the Horseshoe-shaped Belt comprises a large number of countries such as Chile, Argentina, Bolivia, Peru, Colombia, Panama, Costa Rica, Nicaragua, El Salvador, Honduras, Guatemala, Mexico, the United States and Canada.

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International

Preparations for Pope Francis’ funeral, in figures

The funeral of Pope Francis this Saturday, the first of a reigning pontiff for two decades, is an event that moves dizzying figures and will require the full mobilization of Italian authorities and volunteers.

These are some of the figures that draw what can be expected tomorrow for a historic day:

The Italian Ministry of the Interior has calculated that 200,000 faithful will attend the funeral of Francis. For the next conclave – with a date yet to be defined – and the election of the new pope, that figure amounts to 250,000.

The funeral procession that will move the remains of the late pope from St. Peter’s Vatican to the Basilica of Santa María la Mayor, where Francis arranged to be buried in a simple tomb.

3,000 volunteers will mobilize the Italian Civil Protection, responsible for the management of the preparations. There will be 55 health teams distributed throughout the funeral procession between San Pedro del Vaticano and the basilica de Santa María la Mayor, in addition to 11 advanced medical posts and 52 additional ambulances that will join the existing fleet.

17 degrees and a radiant sun are expected at 10:00 (08.00 GMT) on Saturday, the start time of the funeral, although the thermometer could reach 24 degrees throughout the day.

The state group Ferrovie dello Stato makes 260,000 seats available to those who wish to approach Rome by train. Civil Protection also confirmed that 500 parking spaces for buses and coaches have been reserved for the same day in Rome and its surroundings.

130 international delegations have already confirmed their presence at the event, but it is expected that the final figure may rise to 170. Fifty will be headed by heads of state or government, including a dozen sovereigns.

120,000 arrivals planned in Rome on April 25 and 26, which will translate into about 320,000 overnight stays, according to figures from the Department of Tourism of the Italian capital, which warns that the estimates may be below even those that finally occur. 101,000 of those arrivals will take place in hotels and another 53,000 in “supplementary establishments”.

11,000 soldiers and members of the security forces, not counting the teams of the international delegations, who will ensure that the funeral is held without incident. Police, police officers and traffic officers will join at least 1,500 soldiers.

5 anti-drone bazooas, capable of intercepting the radio frequencies with which these devices are operated, which will reinforce the decreed no-fly zone over the Roman sky.

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International

“A dignified life” for migrants, the plea in Panama in memory of Pope Francis

Catholics who work with some of the 299 migrants deported by the United States to Panama, beg the Government that beyond placing the flag at half-mast for the death of Pope Francis this week, it should pay tribute to him by giving “a dignified life” to the migrants, as the Supreme Pontiff preached.

“Never forget your human dignity,” because “you are not a discard,” the pope wrote last year in a message addressed to the thousands of migrants who had just crossed the dangerous Darién jungle, the natural border between Colombia and Panama, on their way to the United States.

Known by many as “the pope of migrants” for his defense of those who are forced to leave their land in search of better living conditions, he himself recalled then that he was “son of migrants who went out in search of a better future,” and that “there were times when they were left with nothing, until they went hungry; with empty hands, but their hearts full of hope.”

Therefore, members of Catholic organizations that are part of the CLAMOR Network (the Latin American and Caribbean Ecclesiastical Network for Migration, Displacement, Refuge and Trafficking in Persons), and who work with dozens of migrants in the Panamanian capital deported by the United States, remember the teachings of Pope Francis.

Elías Cornejo, coordinator of social promotion and attention to the migrant population of the Catholic organization Fe y Alegría, which is part of the Clamor Network, explained to EFE in a migrant shelter that we must “look for alternatives for these people, they cannot be kept in conditions that are not favorable or dignified.”

“In the context of the death of Pope Francis, who was incisive in insisting on humane treatment of migrants, I believe that this country that declares itself mostly Catholic (…) beyond the flag at half-mast, I would also ask the national government to dignify that memory of Pope Francis by giving an answer to many people who (…) have the right to have a dignified life,” Cornejo stressed.

“Give them that, try to find a human, Christian, evangelical answer,” he insisted.

The pilgrimage of this group of migrants through Panama began in mid-February, when a total of 299 arrived on three planes from the United States within the framework of an agreement that turned the Central American nation into a “joup” country for their repatriation.

Coming from extracontinental nations such as China, Afghanistan, Sri Lanka, Vietnam, Uzbekistan, Cameroon, Ethiopia, Iran, Russia, Pakistan or Nepal, 188 returned to their countries “voluntarily”, according to the latest official information available, and 111 refused to do so, many of them fearing for their lives.

The entire group was first housed in a central hotel in the Panamanian capital, and those who refused to be repatriated to their countries were transferred to a shelter more than 200 kilometers away, near the Darién jungle.

Then, after the decision last March by the Government of Panama to grant them a temporary humanitarian permit for 30 days, extendable up to 90, to find a way out of their situation, they took them back to the capital, although now without any type of logistical support, so the CLAMOR Network occupied that vacuum by first hosting the migrants in a humble hotel in the city, to transfer them days later to one of its shelters.

According to Cornejo, who underlines the support they receive in the shelter of “non-believing people, believing people, Muslim people, people of other religions too,” of the 69 migrants who moved there – families with children continue to stay in a hotel – 47 remain, since they “make their own decisions and move” by their own decision to other places.

“We don’t know where, we have an idea, but we don’t want to keep them or force them to anything, because they are free, they are not people who are imprisoned (…) We don’t want to pressure them, we don’t want to pressure the Government, but we do want to tell them again, ‘please, let’s find a way out of this’. An exit that has to be worthy for the State and for them, for migrants,” he remarked.

At least, he says, from the Foreign Ministry they have guaranteed that they will not deport anyone by force if the new 60-day period ends, an extension that ends in June and that, according to official data shared with EFE, at least 80 migrants have requested.

Two mothers from Asian countries who requested with their children the extension of the “temporary resident permit for humanitarian reasons”, as indicated in the document to which EFE had access, and who asked for anonymity, insisted that returning to their country is not an option, since if they return their “lives are in danger”.

Housed in a humble hotel in the center of the Panamanian capital, on a floor where behind each door there is a family of different nationality, they explain to EFE through a translation application part of their journey to the United States, crossing several countries of America with their minor children, and then their sudden expulsion without knowing the destination, some handcuffed hand and foot.

“When they put me on the plane I felt suffocated. His hands and feet were cold. My heart was beating fast, I had high blood pressure. I told the military,” recalls one of them. There were men and women handcuffed, the children were terrified. They are adults, but children are not, “how can they treat them as criminals?”

Now, they say, they are “afraid” that the day will come when the deadline they were given to stay in Panama will expire. “When this document ends, I don’t know exactly what will happen to us if the United States doesn’t get us out of here.”

“We want to ask Donald Trump to return us to the United States, please,” they begged.

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