International
Treatment improves cognition in Down Syndrome patients
AFP
A new hormone treatment improved the cognitive function of six men with Down Syndrome by 10-30 percent, scientists said Thursday, adding the “promising” results may raise hopes of improving patients’ quality of life.
However the scientists emphasised the small study did not point towards a cure for the cognitive disorders of people with Down Syndrome and that far more research is needed.
“The experiment is very satisfactory, even if we remain cautious,” said Nelly Pitteloud of Switzerland’s Lausanne University Hospital and co-author of a new study in the journal Science.
Down Syndrome is the most common genetic form of intellectual disability, occurring in around one in 1,000 people, according to the World Health Organization.
Yet previous research has failed to significantly improve cognition when applied to people with the condition, which is why the latest findings are “particularly important”, the study said.
Recent discoveries have suggested that how the gonadotropin-releasing hormone (GnRH) is produced in the brain can affect cognitive functioning such as memory, language and learning.
GnRH hormones regulate how much testosterone and estrogen is produced and increased levels of it help spur puberty.
“We wondered if this hormone could play any role in establishing the symptoms of people with Down Syndrome,” said Vincent Prevot, study co-author and head of neuroscience research at France’s INSERM institute.
– Mice research –
The team first established that five strands of microRNA regulating the production of GnRH were dysfunctional in mice specifically engineered for Down Syndrome research.
They then demonstrated that cognitive deficiencies — as well as loss of smell, a common symptom of Down Syndrome — were linked to dysfunctioning GnRH secretion in the mice.
The team then gave the mice a GnRH medication used to treat low testosterone and delayed puberty in humans, finding that it restored some cognitive function and sense of smell.
A pilot study was conducted in Switzerland involving seven men with Down Syndrome aged 20 to 50.
They each received the treatment through their arm every two hours over a period of six months, with the drug delivered in pulses to mimic the hormone’s frequency in people without Down Syndrome.
Cognition and smell tests were carried out during the treatment, as were MRI scans.
Six of the seven men showed improvement in cognition with no significant side effects — however none showed a change in their sense of smell.
“We have seen an improvement of between 10-30 percent in cognitive functions, in particular with visuospatial function, three-dimensional representation, understanding of instructions as well as attention,” Pitteloud said.
The patients were asked to draw a simple 3D bed at several stages throughout the therapy. Many struggled at the beginning but by the end the efforts were noticeably better.
– ‘Improve quality of life’ –
The authors acknowledged some limitations of the study, including its size and that the choice of patients was “pushed by their parents”.
“The clinical trial only focused on seven male patients — we still have a lot of work to do to prove the effectiveness of GnRH treatment for Down Syndrome,” Pitteloud said.
A larger study involving a placebo and 50 to 60 patients, a third of them women, is expected to begin in the coming months.
“We are not going to cure the cognitive disorders of people with Down Syndrome, but the improvement seen in our results already seems fundamental enough to hope to improve their quality of life,” Pitteloud said.
Fabian Fernandez, an expert in cognition and Down Syndrome at the University of Arizona who was not involved in the research, hailed the “tour de force study”.
He told AFP that while it is “difficult to envision” how such an intensive treatment could be used for young people, it might be better suited to delay the Alzheimer’s disease-related dementia suffered by many adults with Down Syndrome.
It was also difficult to predict how such an improvement could impact the lives of people with the condition, he said.
“For some, it could be significant, however, as it would enable them to be more independent with daily living activities such as maintaining and enjoying hobbies, finding belongings, using appliances in the home, and travelling alone.”
International
Indigenous candidate Leonidas Iza predicts a new social explosion if there is no change in Ecuador
The presidential candidate of Ecuador for the indigenous movement, Leonidas Iza, who was part of the wave of protests of 2019 and who led that of 2022, reveals himself as an “anti-system” politician in the face of “a corrupt system” that he intends to reformulate to relieve the impoverished, because he predicts a new social explosion if there is no change in the Government to meet popular demands.
Iza, 42, is the candidate of Pachakutik, the political arm of the Confederation of Indigenous Nationalities of Ecuador (Conaie) that he himself presides over, and with which he was at the forefront of the 2022 wave of protests against the government of conservative President Guillermo Lasso, where he was arrested and even labeled a “terrorist.”
“I am one of those who has never lost the ability to be outraged when governments have had policies against their own citizens,” Iza, a native of the Andean province of Cotopaxi, said in an interview with EFE.
“I am not against the private sector, I am against those who do not pay taxes and those who come to the Government only to defend their companies,” said the candidate in reference to the last two presidents (Lasso and Daniel Noboa).
“We fight for social justice, not to be violent. It is a reaction to the injustice to which we have been subjected,” he said.
For Iza, who represents the anti-extractivist left of Ecuador, the country has “a corrupt system, a health system that does not work, a deficient and unfair economic system, and public services that are not helping citizens.”
“And that’s what we want to change. We won’t be able to do it overnight, but the State can give relief to the people,” the candidate said.
To do this, it proposes to fight against tax evasion, which amounts to about 7.5 billion dollars a year, and also against corruption, which is estimated at about 3 billion dollars per year, to balance public accounts without having to follow the current credit program with the International Monetary Fund (IMF) that asks to cut public spending and raise taxes.
He also aimed to increase agricultural productivity, as well as boost tourism to go from 1 to 3 million visitors a year, and anticipated that he will regulate small and artisanal mining to avoid illegal mining but will not allow large-scale mining because it considers that it can contaminate the country’s large river basins.
Iza anticipated that he will not pay the external debt as long as there are “guaguas (children, in Kichwa) who have no education and are dying of hunger, and colleagues who are dying for lack of health.”
“We will tell the IMF and the other multilaterals that we are going to pay, but first we are going to solve the structural problem we have at the moment: education, health and minimum conditions for security,” he warned.
In that sense, Iza pointed out that “the strength of a popular reaction in the streets is accumulating” that must be resolved by whoever is elected. “Knowing my country, which has been on the streets all its life, there will be a popular reaction if (the discomfort) is not resolved in the following months,” he reiterated.
“The option that understands the people is us, and not the sectors that have always been in the Government,” said Iza, who avoided pointing out whether that reaction will reach the dimensions of the strong protests of 2019 and 2022, both led by the indigenous movement.
In this electoral campaign, Iza has left his distinctive Andean red poncho to put on the bulletproof vest in the face of the persistent wave of violence of organized crime that the country is experiencing, because he warned that the “war” that Noboa declared to the criminal gangs has not worked because its leaders are still free.
Faced with this, he promised “a hard hand for all” and recalled that “state institutions must suffocate everyone (criminals)”.
The candidate also advocated deepening international cooperation: “there must be a responsibility of all countries (producers, consumers and drug transit), especially in the region (of Latin America)”.
Asked if Ecuadorian society is ready to have an indigenous president of rural origin, Iza sees himself with popular support to face “the most reactionary sectors that have support in racism and stigmatization.”
International
Deaths in a hotel fire in a ski resort in Turkey rise to 69
The fire that occurred this morning in a 12-story hotel in a ski resort in northwestern Turkey claimed at least 69 deaths, in addition to causing fifty injuries, according to the latest assessment of the country’s authorities.
The fire originated around 3.30 a.m. local time (0.30 GMT) in a hotel, built entirely of wood, in the Kartalkaya ski center, halfway between Istanbul and Ankara, with almost full occupancy.
The flames were extinguished after about ten hours of firefighters’ work and the authorities found the death of 66 people, in addition to rescuing 51 injured, compared to the 10 dead and 32 injured initially estimated.
The hotel, with 161 rooms, had an occupancy close to 90%, because these days are the winter school holidays in Turkey, says the Turkish newspaper Hürriyet.
The wooden construction and the location of the hotel at the foot of a ski slope, which only allows vehicle access from the front facade, made the intervention of firefighters difficult, the Turkish newspaper explained.
According to the television network NTV, about 300 people, including employees, were in the hotel at the time of the fire, the causes of which are still unknown.
International
Hamas calls for counterattack on Israeli soldiers during their incursion in the West Bank
The Islamist organization Hamas urged the Palestinians on Tuesday to intensify and support their militiamen in the clashes against the Israeli Army during the military incursion that began today in Yenin, in the north of the occupied West Bank.
“We call on the masses of our people in the West Bank and their revolutionary youth to mobilize and intensify the clashes against the (Israeli) occupation army at all points, and to work to thwart the extensive Zionist aggression against the city of Yenin.”
“This military operation launched by the occupation in Yenin will fail, as did all its previous military operations against our brave people and their tenacious resistance,” the Palestinian group said.
Since the beginning of the operation, nicknamed by the Army “Iron Wall”, at least seven Palestinians have died in Yenin and another 35 have been injured, according to data from the Palestinian Ministry of Health.
Hamas accused the forces of the Palestinian National Authority (ANP), President Mahmoud Abbas’ ruling party in the West Bank, of having left Yenin to allow the operation of Israeli troops, instead of defending the Palestinians.
Israeli Prime Minister Benjamin Netanyahu defended on Tuesday that the last assault launched by his forces against Yenin, in the north of the occupied West Bank, seeks to “eradicate terrorism.”
“This is another step towards the objective we have set ourselves: to strengthen security in Judea and Samaria (West Bank),” according to a statement released by its Office.
“We are acting systematically and decisively against the Iranian axis wherever it sends its weapons: in Gaza, Lebanon, Syria, Yemen, Judea and Samaria (West Bank),” concludes the Israeli president’s note.
The rail comes shortly after the start of the ceasefire in Gaza, which includes a weekly exchange of hostages in the Strip for Palestinian prisoners in Israeli prisons.
Following the release of the prisoners, the Army increased its presence in this occupied territory with seven companies, claiming to strengthen its “anti-terrorist efforts.”
The images recorded in Yenin show dozens of Army vehicles accessing the local refugee camp, which has also been bombed by Israeli aviation.
The incursions and attacks of Israeli forces in Yenin, considered a bastion of Islamist-like militias, were already constant but they worsened after the Hamas attacks of October 7, 2023.
However, since mid-December it has been the security forces of the Palestinian National Authority (ANP), which governs small parts of the West Bank, that have led an offensive in this population, which until last Friday triggered armed fighting against the militiamen.
This exchange of fire has caused at least 15 people dead on both sides, including two minors.
The occupied West Bank is experiencing its greatest spiral of violence since the Second Intifada (2000-05), and in 2024 at least 491 Palestinians have died in the territory by Israeli fire, most of them militiamen from refugee camps, but also civilians, including at least 75 minors, according to EFE’s count.
So far this year, at least 24 Palestinians have already died in Israeli attacks, five of them minors.
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