International

Cancer drug cooperation could save 1.5 mn lives a year: researchers

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AFP

Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.

The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.

Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.

More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.

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The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.

Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.

The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.

Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.

That represents roughly 1.5 million of the around 10 million people who die of cancer every year.

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‘Challenging’ for doctors

“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.

Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.

The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.

But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.

The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.

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“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.

International

Young Spanish Woman Receives Euthanasia After Legal Battle, Sparking Debate

A 25-year-old Spanish woman, Noelia Castillo, received euthanasia on Thursday following a prolonged legal dispute with her father.

She passed away at a care center in Sant Pere de Ribes, about 40 kilometers from Barcelona, where she had been living for some time, according to Spanish media reports.

In an interview broadcast a day earlier on Antena 3, Castillo expressed her exhaustion after enduring prolonged suffering. She indicated that her decision was influenced by a combination of personal circumstances and health-related challenges, including family conflicts and a condition of paraplegia following a previous incident that left her with lasting physical consequences.

Spain legalized euthanasia in 2021, becoming one of the few countries that allow patients under strict conditions to seek medical assistance to end their lives in order to avoid what the law defines as unbearable suffering.

The case has reignited debate in Spain over the ethical, legal, and family dimensions surrounding euthanasia, as well as the broader issue of support for individuals in vulnerable situations.

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International

Over 300 U.S. Troops Wounded Since Start of Iran Conflict, CENTCOM Says

More than 300 U.S. service members have been injured since the start of the conflict with Iran on February 28, the United States Central Command confirmed on Friday.

“Since the beginning of Operation Epic Fury, approximately 303 U.S. service members have been wounded. The vast majority of these injuries are minor, and 273 troops have already returned to duty,” said U.S. Navy Captain Tim Hawkins.

A U.S. official, speaking on condition of anonymity to AFP, indicated that 10 American troops remain seriously injured.

According to the latest figures, an additional 13 U.S. service members have been killed since the conflict began, including seven in the Gulf region and six in Iraq.

Meanwhile, Iran’s armed forces warned on Friday that hotels hosting U.S. troops in the region could be considered legitimate military targets.

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“When U.S. forces enter a hotel, from our perspective that hotel becomes American,” said armed forces spokesperson Abolfazl Shekarchi in remarks broadcast on state television.

International

Iran rejects negotiations as tensions escalate with United States

Iran has no intention of entering negotiations and will continue to resist, Foreign Minister Abbas Araghchi said Wednesday night, dismissing recent statements by U.S. President Donald Trump about possible talks.

Speaking to state television, Araghchi argued that Washington’s call for negotiations reflects a position of weakness. He added that the Islamic Republic seeks to end the war on its own terms, ensuring that such a conflict does not recur in the future.

Meanwhile, the White House issued a stark warning, stating that Trump would “unleash hell” on Iran if it refuses to accept a deal to end the conflict. Despite Tehran’s rejection, U.S. officials maintained that discussions remain ongoing.

White House spokesperson Karoline Leavitt reinforced the administration’s position, warning that failure to acknowledge what she described as Iran’s military defeat would result in even stronger action from Washington.

The increasingly aggressive rhetoric from both sides has diminished hopes for a near-term de-escalation in the conflict, which began following U.S. and Israeli strikes against Iran on February 28.

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As tensions continue to rise, the prospect of a diplomatic resolution remains uncertain amid conflicting narratives and escalating threats from both governments.