International

Cancer drug cooperation could save 1.5 mn lives a year: researchers

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AFP

Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.

The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.

Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.

More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.

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The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.

Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.

The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.

Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.

That represents roughly 1.5 million of the around 10 million people who die of cancer every year.

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‘Challenging’ for doctors

“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.

Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.

The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.

But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.

The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.

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“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.

International

Federal immigration agents kill man in Minneapolis, sparking protests and outrage

Federal immigration agents shot and killed a 37-year-old Minneapolis man during an operation on Saturday, authorities confirmed, sparking new protests and deepening outrage over federal immigration enforcement in the city.

The victim, identified as Alex Jeffrey Pretti, was a U.S. citizen and intensive care nurse who worked at a Veterans Affairs hospital and was widely respected in his community, according to colleagues and news reports.

Officials said the shooting occurred during a targeted immigration raid in south Minneapolis. The Department of Homeland Security (DHS) described the incident as an act of self-defense by agents who believed the man posed a threat.

However, videos reviewed by multiple outlets and eyewitnesses show Pretti holding a phone and not displaying a weapon before being pepper-sprayed, tackled by agents and then shot multiple times, raising serious questions about the official account.

The killing comes amid a broader federal immigration enforcement operation in the city and follows another controversial shooting in early January in which Renée Good, a 37-year-old U.S. citizen, was fatally shot by an ICE agent, leading to widespread protests and criticism of federal tactics.

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International

Delcy Rodríguez seeks political agreements after Maduro’s ouster

Venezuela’s interim president, Delcy Rodríguez, on Saturday called for “reaching agreements” with the opposition to achieve “peace” in the country, which the United States says it now controls following the military operation that removed President Nicolás Maduro from power.

Rodríguez, who previously served as Maduro’s vice president, assumed interim leadership after the leftist leader was captured on January 3 during a military incursion that left nearly 100 people dead.

In her first public statements since taking office, Rodríguez signaled a shift in the strained relationship between Caracas and Washington, while also committing to the release of a “significant number” of political prisoners.

“There can be no political or partisan differences when it comes to the peace of Venezuela,” Rodríguez said during an address in the coastal state of La Guaira, broadcast on state television VTV.

“From our differences, we must speak to one another with respect. From our differences, we must meet and reach agreements,” she added.

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The day before, Rodríguez instructed the head of Parliament — her brother Jorge Rodríguez — to convene talks with various political sectors in the country aimed at achieving “concrete and immediate results.”

International

Bogotá and Quito Seek Dialogue After Tariffs and Power Cut Escalate Tensions

Bogotá and Quito will hold an emergency bilateral summit next week amid recent developments that have strained relations between the two countries.

Tensions escalated this week after Ecuadorian President Daniel Noboa unexpectedly announced a 30% tariff on Colombian imports. Colombia responded with a reciprocal measure, imposing the same tariff on around 20 Ecuadorian products and suspending electricity exports to Ecuador.

Aware that electricity imports are critical to easing Ecuador’s recent energy crises, Quito further imposed a 30% tariff on the transportation of Colombian oil through its territory.

However, recent statements from the Ecuadorian government suggest that dialogue between the two sides has intensified in recent hours. Ecuador’s Minister of Foreign Affairs, Gabriela Sommerfeld, confirmed that active conversations are under way.

In Colombia, segments of the business sector have welcomed the prospect of negotiations. The National Business Council (Consejo Gremial Nacional, CGN), for instance, urged both governments to restore commercial relations, warning that the dispute “puts jobs and regional economic stability at risk.”