International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
Police investigate deaths of Rob Reiner and wife as apparent homicide
The Los Angeles Police Department (LAPD) is investigating the deaths of Hollywood actor and filmmaker Rob Reinerand his wife as an “apparent homicide,” amid a wave of tributes to the director of classics such as When Harry Met Sally.
According to U.S. media reports on Sunday, Rob Reiner and Michele Singer Reiner were found dead at their Los Angeles mansion with what appeared to be stab wounds.
Several political figures shared messages of condolence following the reported deaths of the director of A Few Good Menand his wife.
While the LAPD did not officially confirm the identities of the victims, it stated that homicide detectives were dispatched to the Reiner residence.
“At this time, no additional details are available and the investigation into an apparent homicide is ongoing,” the Los Angeles Police Department said in a statement posted on social media.
LAPD Deputy Chief Alan Hamilton told reporters that no arrests have been made and that no individuals are currently being questioned as suspects.
“I’m not going to confirm whether anyone is being questioned at this moment or not. We are going to try to speak with as many family members as we can,” Hamilton said.
CNN reported that a family spokesperson confirmed the deaths of Reiner and his wife.
California Governor Gavin Newsom, former U.S. President Barack Obama, and former Vice President Kamala Harrisissued statements expressing their condolences.
International
U.S. and Mexico Reach Deal to Address Water Deficit Under 1944 Treaty
The United States and Mexico have reached an agreement to comply with current water obligations affecting U.S. farmers and ranchers and for Mexico to cover its water deficit to Texas under the 1944 Water Treaty, the U.S. Department of Agriculture said in a statement.
The department уточified that the agreement applies to both the current cycle and the water deficit from the previous cycle.
On Monday, U.S. President Donald Trump accused Mexico of failing to comply with the water-sharing treaty between the two countries, which requires the United States to deliver 1.85 billion cubic meters of water from the Colorado River, while Mexico must supply 432 million cubic meters from the Rio Grande.
Mexico is behind on its commitments. According to Washington, the country has accumulated a deficit of more than one billion cubic meters of water over the past five years.
“This violation is severely harming our beautiful crops and our livestock in Texas,” Trump wrote on Monday.
The Department of Agriculture said on Friday that Mexico had agreed to supply 250 million cubic meters of water starting next week and to work toward closing the shortfall.
Agriculture Secretary Brooke Rollins, quoted in the statement, said Mexico delivered more water in a single year than it had over the previous four years combined.
Trump has said that if Mexico continues to fall short of its obligations, the United States reserves the right to impose 5% tariffs on imported Mexican products.
Mexico’s Deputy Foreign Minister for North America, Roberto Velasco, said that a severe drought in 2022 and 2023prevented the country from meeting its commitments.
International
Several people shot in attack on Brown University campus
Several people were shot on Saturday in an attack on the campus of Brown University, in the northeastern United States, local police reported.
“Shelter in place and avoid the area until further notice,” the Providence Police Department urged in a post on X. Brown University is located in Providence, the capital of the state of Rhode Island.
U.S. President Donald Trump said on his social media platform Truth Social that he had been briefed on the situation and that the FBI was on the scene.
At 5:52 p.m. local time (11:52 p.m. GMT), Brown University said the situation was still “ongoing” and instructed students to remain sheltered until further notice.
After initially stating that the suspect had been taken into custody, Trump later posted a second message clarifying that local police had walked back that information. “The suspect has NOT been apprehended,” the U.S. president said.
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