International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
Archbishop Wenski criticizes Trump’s deportation policies, calls for stronger push for reform
The Archbishop of Miami, Thomas Wenski, has called for increased pressure on the U.S. Congress to advance comprehensive immigration reform and criticized President Donald Trump’s mass deportation policies, arguing that they “do nothing to help.”
“We need to apply more pressure on Congress so lawmakers can make the necessary changes. It is also important for the Administration to listen to our voice. We do not want to be anyone’s enemy—we are Americans,” Wenski said in an interview with EFE.
The religious leader, who heads one of the dioceses with the largest Latino and Haitian populations in the United States, issued a call to defend the rights of migrants. He also emphasized that the U.S. Conference of Catholic Bishops (USCCB) has maintained a strong and public stance in favor of migrants for decades.
International
Trump relaunches diplomatic push to finalize U.S.-Backed peace plan for Ukraine War
U.S. President Donald Trump announced on Tuesday that his diplomatic team will resume meetings with delegations from Russia and Ukraine in an effort to pressure both sides to accept the peace plan proposed by Washington to end the war in Ukraine.
As part of this new round of talks, U.S. Special Envoy Steve Witkoff will travel to Moscow to meet with Russian President Vladimir Putin. Meanwhile, Army Secretary Dan Driscoll will hold discussions with Ukrainian representatives to narrow differences on the remaining points of the agreement.
Trump also confirmed his intention to meet personally with Ukrainian President Volodymyr Zelensky and with Putin, though he emphasized that such meetings will only take place “when the agreement is fully finalized or in its final stage.”
The president claimed that his administration has made “tremendous progress” toward resolving the conflict and reiterated that the war “never would have started” if he had been in the White House at the onset of the crisis.
The U.S.-backed peace plan consists of 28 points and has been revised following feedback from both sides. According to Trump, only “a few points of disagreement” remain under active discussion.
One of the most controversial aspects of the proposal is the suggestion that Ukraine cede parts of the Donbas region to Russia and limit the size of its armed forces. Kyiv is working closely with Washington to soften these clauses in search of an arrangement that does not compromise its sovereignty or security.
With this diplomatic push, Trump aims to solidify his role as the main mediator in the conflict and steer the war toward a political resolution after years of devastation, humanitarian crisis, and rising global geopolitical tensions.
International
Man pleads not guilty in Liverpool parade incident that injured more than 130
Paul Doyle, who has been held in provisional detention since the incident, is accused of intentionally injuring 12 people, attempting to injure another 17, and committing acts of violence and dangerous driving.
According to prosecutors, eight of the victims were minors at the time, including a six-month-old baby.
Wearing a black suit, the 54-year-old defendant broke into tears as the jury entered Liverpool Crown Court, in northwest England. Doyle, a father of three and former member of the Royal Navy, had pleaded not guilty in September to the 31 charges against him.
On Tuesday, he reaffirmed his not-guilty plea when asked to respond again to four of the charges, which had been slightly amended. The jury was sworn in the same day, and the trial—expected to last three to four weeks—will begin on Wednesday.
The incident occurred on May 26, when thousands of Liverpool FC supporters were gathered for a parade celebrating the club’s Premier League victory. According to the investigation, Doyle’s car entered a street that had just been reopened to allow an ambulance through.
His vehicle was then surrounded by a crowd of Liverpool supporters, some of whom acted aggressively. Doyle first reversed, then accelerated forward, swerving and striking people on both sides of the street. According to an initial report from Merseyside Police, 134 people were injured.
Firefighters reported that one man was thrown onto the hood of the vehicle and four people, including a child, were trapped underneath the car.
Doyle was arrested at the scene. Police quickly ruled out any terrorist motive, stating instead that it was an isolated incident.
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