International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
Senate Bipartisan Vote Moves Measure to Block Further U.S. Military Action in Venezuela
The U.S. Senate took a significant step on Thursday toward limiting President Donald Trump’s military authority in Venezuela, advancing a bipartisan war powers resolution that would block further military actions without explicit congressional approval, lawmakers said.
In a 52-47 procedural vote, the measure moved forward after five Republican senators joined all Democrats in supporting the effort. The resolution aims to require presidential authorization from Congress before the United States can engage in any new hostilities against Venezuela, a rare rebuke of Trump from both sides of the aisle following the controversial military operation that resulted in the capture of Venezuelan leader Nicolás Maduro.
If ultimately passed, the legislation would obligate the administration to withdraw U.S. forces from any imminent hostilities in or against Venezuela unless Congress explicitly authorizes such actions. However, the measure’s future remains uncertain as it heads next to the House of Representatives, where a Republican majority is less likely to approve it, and any final version would likely face a presidential veto. Overriding a veto would require a two-thirds majority in both chambers, a high threshold in the current political landscape.
President Trump has sharply criticized Republican senators who broke ranks to support the resolution, saying they should not be re-elected and arguing that the measure undermines his authority to act in national defense. Nevertheless, the vote signals growing bipartisan concern in Congress about unchecked executive military action in the absence of legislative authorization.
International
Petro and Trump Agree on Joint Action Against ELN Guerrillas After Tense Diplomacy
Colombian President Gustavo Petro and his U.S. counterpart Donald Trump agreed on “joint actions” to combat the National Liberation Army (ELN) guerrilla group operating along the Colombia–Venezuela border, Colombia’s Interior Minister Armando Benedetti said on Thursday.
The announcement came after a period of heightened diplomatic tension triggered by recent U.S. airstrikes in Venezuela, the capture of Venezuelan President Nicolás Maduro, and threats of possible U.S. military action in Colombia. The phone call Wednesday evening was the first direct conversation between Petro and Trump since both leaders took office, and it helped ease the strained relationship.
During the call, both presidents committed to carry out joint efforts against the ELN, a guerrilla group that has repeatedly attacked Colombian security forces and is accused of kidnapping soldiers. In December, the ELN declared a “armed strike,” confining civilians in areas under its control in response to perceived threats of U.S. intervention.
According to Benedetti, Petro welcomed Trump’s invitation to meet in Washington and asked for U.S. support to “strike hard” against ELN positions along the porous border with Venezuela, where guerrillas often flee after clashes with Colombian forces.
The border region is a longstanding flashpoint, where armed groups, drug traffickers and illegal mining networks compete for control. Previous attempts by Petro’s government to negotiate peace with the ELN have stalled after a major offensive in Catatumbo that left hundreds dead and displaced thousands.
International
Lula Vetoes Bill That Would Have Shortened Bolsonaro’s Prison Sentence
Brazilian President Luiz Inácio Lula da Silva vetoed on Thursday a bill that would have significantly reduced the prison sentence of his far-right predecessor, Jair Bolsonaro, who is currently serving time for attempting a coup d’état.
Despite the veto, the conservative-majority Congress retains the power to override the decision through a vote.
In September, following a landmark trial, Brazil’s Supreme Court sentenced Bolsonaro to 27 years in prison after finding him guilty of conspiring to remain in power in an “authoritarian” manner following his defeat to Lula in the 2022 presidential election.
The 70-year-old former president has been incarcerated in a Brasília prison since late November. Earlier this month, the Supreme Court rejected a request for house arrest on health grounds.
Under the current legal framework, Bolsonaro would be required to serve approximately eight years before becoming eligible for sentence leniency. However, a bill passed by Congress in December could have reduced that period to just over two years, prompting Lula’s veto.
Senate Bipartisan Vote Moves Measure to Block Further U.S. Military Action in Venezuela
Petro and Trump Agree on Joint Action Against ELN Guerrillas After Tense Diplomacy
Lula Vetoes Bill That Would Have Shortened Bolsonaro’s Prison Sentence
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