International

Cancer drug cooperation could save 1.5 mn lives a year: researchers

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AFP

Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.

The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.

Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.

More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.

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The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.

Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.

The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.

Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.

That represents roughly 1.5 million of the around 10 million people who die of cancer every year.

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‘Challenging’ for doctors

“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.

Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.

The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.

But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.

The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.

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“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.

International

Rubio signals possible engagement with Iranian factions amid internal divisions

U.S. Secretary of State Marco Rubio said Monday that Washington is hopeful of engaging with factions within the government of Iran, noting that the United States has received positive private signals.

Speaking to ABC News’ Good Morning America, Rubio suggested that internal divisions exist within the Islamic Republic and expressed confidence that figures with the authority to act could emerge.

“We are hopeful that this will be the case,” Rubio said. “Clearly, there are people there who are communicating with us in ways that those previously in power in Iran did not. This is reflected in some of the steps they appear willing to take.”

Despite this, Rubio maintained a firm stance toward Iran, reiterating that the ongoing conflict seeks to eliminate its capacity to develop nuclear weapons—an objective that President Donald Trump has previously claimed was achieved during a military strike last year.

International

King Charles III to visit the U.S. on first state trip since taking the throne

King Charles III and Queen Camilla will undertake a state visit to the United States on the recommendation of the British government, Buckingham Palace announced on Tuesday, adding that further details will be released at a later date.

The visit aims to highlight the historic ties and current relationship between the United Kingdom and the United States, as both countries prepare to mark the 250th anniversary of American independence in 2026.

The trip is expected to take place at the end of April and follows U.S. President Donald Trump’s visit to the United Kingdom last year, which sought to strengthen bilateral relations.

This will be Charles III’s first state visit to the United States since ascending to the throne in 2022, although he previously traveled there 19 times as Prince of Wales.

By comparison, Queen Elizabeth II made four state visits to the United States—in 1957, 1976, 1991, and 2007—while U.S. presidents have carried out four state visits to the United Kingdom since 1952, in 2003, 2011, 2019, and 2025.

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Following the U.S. trip, the monarch is also expected to travel to Bermuda, marking his first official visit to the territory since becoming head of state.

The visit comes amid tensions between the two countries due to differences between President Trump and British Prime Minister Keir Starmer over the war in Iran. Starmer has reiterated that the United Kingdom will not take part in the conflict, although it will defend its interests and support allies in the Persian Gulf.

Trump has criticized that stance, urging countries not involved in the military campaign to act decisively, stating that “the hardest part is already done.”

The trip also follows a request by U.S. Congressman Ro Khanna, who called on the king to meet privately with victims linked to convicted sex offender Jeffrey Epstein during his stay.

The case has also involved the king’s brother, Prince Andrew, who has faced scrutiny over his past associations with Epstein. The former royal, stripped of his titles and honors, has denied any wrongdoing despite ongoing allegations and investigations.

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International

Leopoldo López thanks Spain for fast-track citizenship but says “I am still Venezuelan”

Venezuelan opposition leader Leopoldo López expressed gratitude on Tuesday to the Government of Spain after being granted Spanish citizenship through an expedited process, following the revocation of his Venezuelan nationality by the administration of Nicolás Maduro.

Speaking in Madrid, López acknowledged the gesture but admitted having mixed emotions. “I am grateful to the Spanish government for granting me citizenship, but I have mixed feelings, as do millions of Venezuelans who have had to leave their country. It is not easy,” he said.

The opposition figure highlighted Spain’s role as a refuge for Venezuelans, while emphasizing that his identity remains unchanged. “Spain has been, for me, my family, and hundreds of thousands of Venezuelans, a homeland away from home. That does not mean we stop being Venezuelan. I am Venezuelan, I carry Venezuela in my heart, and everything I have done has been for Venezuela,” he added.

López requested Spanish nationality after the Venezuelan government stripped him of his citizenship in October, accusing him of promoting a “military invasion,” a move that left him effectively stateless.

Initially, he applied through the standard process in late 2025 but, unable to meet the requirements, later sought nationality through a special mechanism known as “carta de naturaleza,” with the support of Spain’s foreign minister, José Manuel Albares.

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To support his application, López submitted documentation from the Inter-American Court of Human Rights, which determined that he had been a victim of political persecution, arbitrary detention, imprisonment, and other actions by the Venezuelan government.

“For me, this has been a long journey. The persecution by the dictatorship against me began many years ago. I was banned, persecuted, censored, imprisoned, and sentenced to 14 years in prison. I had to escape from Venezuela, from prison,” he said.

Spain’s decision to grant him citizenship through an exceptional procedure was justified by his “very special situation,” including the lack of documentation and legal status.