International

Cancer drug cooperation could save 1.5 mn lives a year: researchers

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AFP

Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.

The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.

Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.

More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.

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The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.

Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.

The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.

Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.

That represents roughly 1.5 million of the around 10 million people who die of cancer every year.

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‘Challenging’ for doctors

“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.

Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.

The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.

But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.

The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.

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“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.

International

Nine People Killed in Two Armed Attacks in Manabí, Ecuador

At least nine people were killed Monday in two nearly simultaneous armed attacks in the province of Manabí, located on Ecuador’s Pacific coast, one of the areas hardest hit by violence in the country, according to the National Police.

The first attack left seven people dead and took place in Camarones, a rural area of the Jama canton. The second occurred in the sector known as La Y, in the seaside town of Canoa, part of the San Vicente canton, where two people were killed.

According to preliminary reports, both incidents occurred early Monday morning when armed men intercepted the victims. Authorities said the motives behind the attacks remain under investigation.

The assault in Camarones happened around 1:15 a.m. local time, when a group of armed individuals stormed a ranch in the area. The victims have not yet been officially identified.

About 15 minutes later, in Canoa, two men traveling in a motorized taxi were intercepted by armed suspects riding motorcycles and shot. One of the victims was identified as a 28-year-old passenger, while the identity of the driver has not yet been confirmed.

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The attacks occurred just days after another multiple homicide on February 12 at a ranch in San Juan de las Cucarachas, a rural area of the Santa Ana canton in Manabí, which left six people dead.

Manabí has been experiencing escalating insecurity linked to disputes among organized crime groups, including drug trafficking networks and territorial control conflicts. In response, the government has maintained a state of emergency in the province since August to address the surge in violence attributed to these criminal organizations.

International

Over 40 Million Affected by Major Snowstorm in Northeastern U.S.

More than 40 million people across the northeastern United States are facing a new major snowstorm this Monday, including residents of New York City, where local authorities have shut down roads to traffic.

The storm triggered widespread flight cancellations early in the morning and caused power outages affecting thousands of homes and businesses throughout the region.

New York City Mayor Zohran Mamdani banned non-essential vehicle travel at least until noon and ordered the closure of public schools as a precautionary measure. Authorities in neighboring states, including New Jersey and Rhode Island, imposed similar restrictions to ensure public safety.

This marks the second major winter storm to hit the East Coast in less than a month, leading to growing frustration among residents.

“I’m fed up. I don’t want to see another snowflake,” said Vincent Greer, a resident of Wildwood, New Jersey, as he shoveled accumulated snow from in front of his building.

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Officials continue to urge residents to remain indoors, avoid unnecessary travel, and monitor local advisories as crews work to clear roads and restore power.

International

Ninth Victim Recovered After Deadliest U.S. Avalanche in Decades

Rescue teams in California on Saturday recovered the body of the ninth and final victim of a deadly avalanche in the Sierra Nevada mountains, according to the local sheriff’s office.

The avalanche struck a group of 11 skiers and four guides on Tuesday as they were returning from a three-day backcountry trip near Castle Peak, a 2,777-meter (9,111-foot) mountain and popular tourist destination on the U.S. West Coast.

Six people were rescued alive on Tuesday. Authorities said the incident marks the deadliest avalanche in the United States since 1981.

“All nine individuals who lost their lives in the February 17 Castle Peak avalanche have been safely recovered from the mountain,” the Nevada County Sheriff’s Office said in a statement.

“There are no words that can truly capture the magnitude of this loss, and our hearts grieve alongside the families affected by this catastrophic event,” Sheriff Shannan Moon said.

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Officials had warned on Thursday that search operations would likely continue through the weekend due to severe weather conditions in the area.

Survivors were able to call for help shortly after the avalanche occurred. However, near-zero visibility and the risk of additional snow slides prevented rescue teams from reaching them for several hours.