International

Cancer drug cooperation could save 1.5 mn lives a year: researchers

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AFP

Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.

The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.

Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.

More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.

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The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.

Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.

The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.

Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.

That represents roughly 1.5 million of the around 10 million people who die of cancer every year.

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‘Challenging’ for doctors

“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.

Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.

The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.

But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.

The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.

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“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.

International

Two killed in shooting at restaurant near Frankfurt Airport

Two people were shot dead early Tuesday at a restaurant in Raunheim, near Frankfurt Airport, according to local police.

Preliminary findings indicate that an armed individual entered the establishment at around 03:45 local time (02:45 GMT) and opened fire on the victims, who died at the scene from their injuries.

The suspect fled and remains at large, while the motive behind the shooting is still unclear, German media reported. Authorities have launched a large-scale search operation.

International

U.S. counterterrorism chief resigns over opposition to war in Iran

Joe Kent, director of the National Counterterrorism Center, announced Tuesday that he has resigned from his post, citing his opposition to the ongoing war in Iran.

In a post on X, Kent said he could not, “in good conscience,” support the conflict, arguing that Iran did not pose an imminent threat to the United States. He also claimed that the war was driven by pressure from Israel and its lobbying influence in Washington.

In a resignation letter addressed to Donald Trump, Kent alleged that at the start of the current administration, senior Israeli officials and influential figures in U.S. media carried out a disinformation campaign that undermined the “America First” platform and fostered pro-war sentiment aimed at triggering a conflict with Iran.

Kent further stated that he could not support sending a new generation of Americans to “fight and die in a war that provides no benefit to the American people and does not justify the cost in American lives.”

Since the United States and Israel launched attacks against Iran on February 28, at least 13 U.S. service members have been killed, while 10 others have been seriously wounded and around 200 have sustained minor injuries, according to a report published by The Wall Street Journal.

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International

German president warns Iran war could spread and disrupt Strait of Hormuz

The president of Germany, Frank-Walter Steinmeier, warned Monday that the war involving Iran could expand and further disrupt shipping through the strategic Strait of Hormuz. He urged a swift end to hostilities between Iran, United States and Israel.

Speaking in Panama City during a joint appearance with Panamanian President José Raúl Mulino, Steinmeier said available information suggests Iran has significant capacity to disrupt maritime traffic through the key oil route.

“Iran has considerable potential to interfere with shipping through the Strait of Hormuz,” Steinmeier said through an interpreter. “We should therefore reach an end to the hostilities as soon as possible and call on all parties involved to make that happen.”

The remarks came during Steinmeier’s visit to Panama, the first by a German president to the Central American nation.

The German leader described the possibility of the conflict spreading as “very dangerous,” saying recent developments indicate that such a scenario cannot be ruled out.

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Over the weekend, U.S. President Donald Trump urged allied nations to help ensure safe passage for ships through the Strait of Hormuz after Iran moved to block the waterway in response to U.S. strikes. However, several allies—particularly in Europe—have shown little support for the proposal.

“Some are very enthusiastic, others are not, and some are countries we have helped for many years,” Trump told reporters at the White House. “We have protected them from terrible external threats, and they’re not that enthusiastic. And the level of enthusiasm is important to me.”

Meanwhile, Kaja Kallas, the European Union’s top diplomat, said the Strait of Hormuz falls “outside NATO’s scope” and stressed that “the war involving Iran is not Europe’s war.”