International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
Rubio rules out 2028 presidential bid if Vance runs
U.S. Secretary of State Marco Rubio said he would not seek the presidency in 2028 if current Vice President JD Vancedecides to run as the Republican nominee to succeed President Donald Trump.
“If JD Vance runs for president, he will be our candidate, and I will be one of the first people to support him,” Rubio said in an interview with Vanity Fair, in which he appeared alongside other senior members of the presidential cabinet.
Rubio, 54, and Vance, 41, are widely viewed as two of the leading Republican figures who could headline the party’s ticket in the 2028 election. Under the U.S. Constitution, Trump is barred from seeking another term after completing two presidential mandates.
In a lighthearted moment during the interview, Vance jokingly offered photographers $1,000 if they managed to make him look better than Rubio in the photos. Both leaders have received public backing from Trump, who last October floated the idea of a joint ticket featuring Rubio and Vance, without clarifying who would lead it.
“I think that if they ever teamed up, they would be unstoppable. I don’t think anyone would run against us,” Trump said at the time.
White House Chief of Staff Susie Wiles, who also took part in the interview, confirmed that Trump does not intend to violate the 22nd Amendment, which prohibits a third presidential term, though she acknowledged that the president is “having fun” with speculation about a possible return to office.
Rubio, the son of Cuban immigrants, served as a Republican senator from 2010 to 2025. He sought the party’s presidential nomination in 2016 but was defeated by Trump after a bruising primary contest. His name was floated as a potential vice presidential pick in 2024, but Vance ultimately secured the spot. After taking office, Trump appointed Rubio as secretary of state, making him the first Latino to hold the position.
International
Authorities search for armed and dangerous suspect in fatal Brown University attack
According to the statement, investigators are “seeking the public’s help to identify and speak with an individual” who was seen “near” the suspect at the time of the attack.
The Providence Police Department in Rhode Island released three photos of the person of interest, whose face has been blurred. In the images, the individual is wearing navy blue clothing, what appears to be a green hood, and carrying a light-colored backpack.
Earlier, authorities had released several photos and videos of a suspect described as “approximately 5 feet 8 inches tall, with a stocky build,” dressed in dark clothing, with their face covered by a surgical mask and wearing a beanie. The suspect’s identity remains unknown.
Authorities are offering a $50,000 reward for any information leading to the identification, arrest, and conviction of the person responsible for the killings, who is considered armed and dangerous.
The gunman opened fire on Saturday at Brown University’s engineering and physics building, where exams were being held, killing students Ella Cook and Mukhammad Aziz Umurzokov. The names of the nine people injured have not been released.
International
Police investigate deaths of Rob Reiner and wife as apparent homicide
The Los Angeles Police Department (LAPD) is investigating the deaths of Hollywood actor and filmmaker Rob Reinerand his wife as an “apparent homicide,” amid a wave of tributes to the director of classics such as When Harry Met Sally.
According to U.S. media reports on Sunday, Rob Reiner and Michele Singer Reiner were found dead at their Los Angeles mansion with what appeared to be stab wounds.
Several political figures shared messages of condolence following the reported deaths of the director of A Few Good Menand his wife.
While the LAPD did not officially confirm the identities of the victims, it stated that homicide detectives were dispatched to the Reiner residence.
“At this time, no additional details are available and the investigation into an apparent homicide is ongoing,” the Los Angeles Police Department said in a statement posted on social media.
LAPD Deputy Chief Alan Hamilton told reporters that no arrests have been made and that no individuals are currently being questioned as suspects.
“I’m not going to confirm whether anyone is being questioned at this moment or not. We are going to try to speak with as many family members as we can,” Hamilton said.
CNN reported that a family spokesperson confirmed the deaths of Reiner and his wife.
California Governor Gavin Newsom, former U.S. President Barack Obama, and former Vice President Kamala Harrisissued statements expressing their condolences.
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