International

Cancer drug cooperation could save 1.5 mn lives a year: researchers

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AFP

Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.

The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.

Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.

More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.

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The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.

Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.

The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.

Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.

That represents roughly 1.5 million of the around 10 million people who die of cancer every year.

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‘Challenging’ for doctors

“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.

Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.

The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.

But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.

The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.

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“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.

International

Chile declares state of catastrophe as wildfires rage in Ñuble and Biobío

Wildland firefighting crews are battling 19 forest fires across the country, 12 of them concentrated in the Ñuble and Biobío regions, located about 500 kilometers south of Santiago.

“In light of the severe fires currently underway, I have decided to declare a state of catastrophe in the regions of Ñuble and Biobío. All resources are now available,” the president announced in a post on X.

Authorities have not yet released an official report on possible casualties or damage to homes.

According to images broadcast by local television, the fires have reached populated areas, particularly in the municipalities of Penco and Lirquén, in the Biobío region, which together are home to nearly 60,000 people. Burned vehicles were also reported on several streets.

“The Penco area and the entire Lirquén sector are the most critical zones and where the largest number of evacuations have taken place. We estimate that around 20,000 people have been evacuated,” said Alicia Cebrián, director of the National Disaster Prevention and Response Service (Senapred), in an interview with Mega TV.

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In recent years, forest fires have had a severe impact on the country, especially in the central-southern regions.

On February 2, 2024, multiple wildfires broke out simultaneously around the city of Viña del Mar, located 110 kilometers northwest of Santiago. Those fires resulted in 138 deaths, according to updated figures from the public prosecutor’s office, and left approximately 16,000 people affected, based on official data.

International

Former South Korean President Yoon sentenced to five years in prison

Former South Korean president Yoon Suk-yeol was sentenced on Friday to five years in prison for obstruction of justice and other charges, concluding the first in a series of trials stemming from his failed attempt to impose martial law in December 2024.

The sentence is shorter than the 10-year prison term sought by prosecutors against the 65-year-old conservative former leader, whose move against Parliament triggered a major political crisis that ultimately led to his removal from office.

Yoon, a former prosecutor, is still facing seven additional trials. One of them, on charges of insurrection, could potentially result in the death penalty.

On Friday, the Seoul Central District Court ruled on one of the multiple secondary cases linked to the affair, which plunged the country into months of mass protests and political instability.

International

U.S. deportation flight returns venezuelans to Caracas after Maduro’s ouster

A new flight carrying 231 Venezuelans deported from the United States arrived on Friday at the airport serving Caracas, marking the first such arrival since the military operation that ousted and captured President Nicolás Maduro.

On January 3, U.S. forces bombed the Venezuelan capital during an incursion in which Maduro and his wife, Cilia Flores, were captured. Both are now facing narcotrafficking charges in New York.

This was the first U.S.-flagged aircraft transporting migrants to land in Venezuela since the military action ordered by President Donald Trump, who has stated that he is now in charge of the country.

The aircraft departed from Phoenix, Arizona, and landed at Maiquetía International Airport, which serves the Venezuelan capital, at around 10:30 a.m. local time (14:30 GMT), according to AFP reporters on the ground.

The deportees arrived in Venezuela under a repatriation program that remained in place even during the height of the crisis between the two countries, when Maduro was still in power. U.S. planes carrying undocumented Venezuelan migrants continued to arrive throughout last year, despite the military deployment ordered by Trump.