International

Cancer drug cooperation could save 1.5 mn lives a year: researchers

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AFP

Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.

The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.

Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.

More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.

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The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.

Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.

The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.

Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.

That represents roughly 1.5 million of the around 10 million people who die of cancer every year.

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‘Challenging’ for doctors

“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.

Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.

The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.

But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.

The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.

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“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.

International

Iran rejects negotiations as tensions escalate with United States

Iran has no intention of entering negotiations and will continue to resist, Foreign Minister Abbas Araghchi said Wednesday night, dismissing recent statements by U.S. President Donald Trump about possible talks.

Speaking to state television, Araghchi argued that Washington’s call for negotiations reflects a position of weakness. He added that the Islamic Republic seeks to end the war on its own terms, ensuring that such a conflict does not recur in the future.

Meanwhile, the White House issued a stark warning, stating that Trump would “unleash hell” on Iran if it refuses to accept a deal to end the conflict. Despite Tehran’s rejection, U.S. officials maintained that discussions remain ongoing.

White House spokesperson Karoline Leavitt reinforced the administration’s position, warning that failure to acknowledge what she described as Iran’s military defeat would result in even stronger action from Washington.

The increasingly aggressive rhetoric from both sides has diminished hopes for a near-term de-escalation in the conflict, which began following U.S. and Israeli strikes against Iran on February 28.

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As tensions continue to rise, the prospect of a diplomatic resolution remains uncertain amid conflicting narratives and escalating threats from both governments.

International

Maduro appears again in New York court amid drug trafficking charges

Ousted Venezuelan president Nicolás Maduro appeared in a New York federal court on Thursday for the second time since his capture on January 3 during a U.S. military operation in Caracas.

Maduro, 63, and his wife, Cilia Flores, 69, have been held in a detention facility in Brooklyn for nearly three months. Their only previous court appearance took place on January 5, when Maduro declared himself a “prisoner of war” and pleaded not guilty to drug trafficking charges.

A large police convoy departed the detention center early in the morning, heading toward the federal courthouse in Manhattan, where the hearing was scheduled. Security around the building was reinforced as both supporters and opponents gathered outside.

Among those present was Venezuelan educator Carlos Egana, who expressed frustration and called for justice, reflecting the polarized reactions surrounding the case. At the same time, left-wing activists displayed banners demanding Maduro’s release and criticizing U.S. foreign policy.

Maduro governed Venezuela from 2013 until his removal from power earlier this year. Following his ouster, Delcy Rodríguez assumed the interim presidency, initiating a shift in relations with the United States.

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The former leader faces multiple charges, including narco-terrorism conspiracy, cocaine importation, and illegal possession of weapons.

During Thursday’s hearing, scheduled for 11:00 a.m. local time, Maduro’s legal team was expected to push for the dismissal of the case, while also addressing disputes over how his legal defense will be financed amid ongoing U.S. sanctions.

His lawyer, Barry Pollack, has argued that restrictions on accessing Venezuelan state funds could affect Maduro’s right to legal representation, adding another layer of complexity to a case with significant political and international implications.

International

German president says trust in U.S. leadership is ‘lost’ amid global tensions

German President Frank-Walter Steinmeier said on Tuesday that trust between the United States and its Western allies has been “lost,” warning that the damage could persist beyond the presidency of Donald Trump.

“The rupture is very deep, and the loss of trust in U.S. great power policy is significant—not only among its allies, but also, as I observe, globally,” Steinmeier said during a speech in Berlin marking the 75th anniversary of Germany’s Foreign Ministry.

Referring to the future of transatlantic relations, he stated that “there is no return to the situation before January 20, 2025,” the date marking the start of Trump’s second term in the White House.

“Even a future U.S. administration will no longer be able to resume the role of a benevolent hegemon guaranteeing a liberal international order,” added Steinmeier, who previously served as Germany’s foreign minister.

He also criticized the war against Iran, describing it as “contrary to international law” and calling it “a political mistake with serious consequences.”

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“This war is avoidable and unnecessary,” he said.

Although the German presidency is largely ceremonial, Steinmeier’s remarks reflect a broader concern within Germany, aligning with the government’s cautious stance while going further in tone.