International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
Iran issues threat to Trump as conflict escalates over Strait of Hormuz
The head of Iran’s Supreme National Security Council, Ali Larijani, threatened U.S. President Donald Trump on Tuesday, warning him to “beware of being eliminated.”
The Republican president had warned on Monday that he would strike Iran “very hard” if the Islamic Republic blocked oil shipments through the Strait of Hormuz, which has effectively been closed since the war began eleven days ago.
“Iran is not afraid of your empty threats. Others more powerful than you tried to destroy the Iranian nation and failed. Beware that you are not eliminated,” Larijani wrote on X.
Earlier, Iran’s Revolutionary Guards — the ideological military force of the Islamic Republic — also said their forces would move to block oil exports from the Gulf.
Meanwhile, Israeli Prime Minister Benjamin Netanyahu said Israel’s military offensive against Iran is far from over.
“Our aspiration is that the Iranian people free themselves from the yoke of tyranny; ultimately, that depends on them. But there is no doubt that with the measures taken so far we are breaking their bones, and we are not finished yet,” Netanyahu said in a statement.
International
Driver detained after suspicious vehicle incident near the White House
The driver was detained and no injuries were reported after an incident that occurred before dawn in Lafayette Square, just north of the White House.
The U.S. Secret Service, which is responsible for presidential security, said in a statement that it was “investigating a suspicious vehicle.” The driver of the car was taken into custody and is currently being questioned.
Washington remains under heightened security measures amid the ongoing conflict involving the United States and Israel against Iran.
Police closed several major streets around the White House. However, by about 8:30 a.m. local time (12:30 GMT), government employees and staff from nearby institutions were allowed to pass through the area with proper identification, according to an AFP journalist at the scene.
Dozens of emergency vehicles with flashing lights responded to the location, while tourists and residents waited for authorities to reopen the streets.
International
Trump Raises Possibility of “Friendly Takeover” of Cuba Amid Deepening Crisis
The President of the United States, Donald Trump, reiterated Monday the possibility that Washington could pursue a “friendly takeover” of Cuba, amid the severe crisis facing the island following the oil blockade promoted by the U.S. government.
Speaking at a press conference in Miami, the president said that U.S. Secretary of State Marco Rubio is currently “negotiating” with representatives of the Cuban government, although authorities in Havana have repeatedly denied that such talks are taking place.
Trump suggested that Washington could play a more direct role in the island’s future.
“It may be a friendly takeover. It may not be a friendly takeover. It wouldn’t matter because they’re really down to, as they say, fumes. They have no energy, they have no money. They are in deep trouble on a humanitarian basis, and we really don’t want to see that,” the U.S. president said.
The president also argued that the Cuban government had long depended heavily on support from Venezuela, particularly oil supplies.
According to Trump, that support has been drastically reduced following measures adopted by Washington.
“They were living off Venezuela. Venezuela doesn’t send them energy, fuel, oil, money, or anything anymore. They couldn’t survive without Venezuela, they couldn’t have made it, and we cut everything off,” Trump said.
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