International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
Washington declares State of Emergency as atmospheric river brings severe flooding
Washington Governor Bob Ferguson declared a state of emergency on Wednesday in response to severe flooding affecting several counties, where more than 75,000 people remain under evacuation alerts following heavy rainfall that has caused significant water accumulation.
An atmospheric river has battered the state since Monday, dropping several centimeters of rain and threatening serious flooding in communities near major rivers. More precipitation is expected in the coming days, and the National Weather Service (NWS) has forecast between 15 and 20 centimeters of rain from Wednesday morning through Thursday afternoon in communities along the far western region, worsening the emergency.
Rainfall totals in higher elevations near the Canadian border could exceed 20 centimeters, further increasing the risk.
“Lives will be at stake in the coming days,” Ferguson warned during a press conference.
The governor underscored the severity of the situation and said he will request an expedited federal disaster declaration from President Donald Trump’s administration to access additional resources for the emergency response.
“I want to urge all Washington residents to pay close attention to alerts from their counties and emergency management departments. If you receive an evacuation order, please follow it,” he added.
Most rivers from the Canadian border down to southwestern Washington are in flood stage. Several are expected to reach record levels, including the Skagit River, which could exceed its 1990 flood peak when water levels rose 1.2 meters.
Around 75,000 people are at risk of flooding in Skagit County, where authorities continue to maintain an evacuation watch.
The Washington National Guard and the U.S. Army Corps of Engineers have been activated to assist with evacuations and response efforts in rural areas affected by flooding.
International
U.S. to require five-year social media history from tourists under Visa Waiver Program
Tourists from 42 countries covered by the U.S. Visa Waiver Program would be required to provide their social media history from the past five years in order to enter the United States, according to a new proposal released Wednesday by the administration of President Donald Trump.
The initiative, led by U.S. Customs and Border Protection (CBP), aims to more thoroughly review the activity of travelers entering the country through the Electronic System for Travel Authorization (ESTA). When asked about the plan’s potential impact on tourism, Trump insisted that the United States is “doing very well.”
“We just want people to come here and be safe… We want to make sure we’re not letting the wrong people into our country,” the president said during a press conference at the White House.
The proposal, published in the Federal Register, seeks to expand the information collected from visitors entering the U.S. for up to three months under the visa waiver program.
ESTA applies to travelers from 42 countries, including the United Kingdom, Ireland, New Zealand, Australia, France, Japan, Israel and Qatar.
In addition to requiring a five-year social media history, the plan would increase the amount of personal data requested, such as phone numbers and email addresses used over the past ten years. It also calls for family details, including names, dates of birth and places of birth of the traveler’s relatives.
The proposal further includes a new mobile tool that would allow any foreign visitor to record their departure from the United States.
International
Six ecuadorian soldiers jailed pending trial for alleged extrajudicial execution
Six Ecuadorian soldiers were placed in pre-trial detention on Wednesday by a civilian court over an alleged extrajudicial execution, the Attorney General’s Office reported.
As part of his war on drug trafficking, President Daniel Noboa declared an internal armed conflict in 2024 and deployed the Armed Forces to the streets. Human rights organizations have since denounced military abuses and a rise in disappearances attributed to state agents.
A judge in the coastal province of Santa Elena ordered pre-trial detention for six soldiers for alleged extrajudicial execution, the prosecution stated on X. It added that the troops, now under investigation for the suspected crime, were in charge of an operation in the resort town of Salinas, during which one of the detainees died.
In a separate case involving alleged abuse of authority, a group of 17 soldiers is currently on trial for the forced disappearance of four minors whose bodies were found burned near an Ecuadorian Air Force (FAE) base.
In December 2024, Saúl Arboleda, Steven Medina, and brothers Josué and Ismael Arroyo — aged 11 to 15 — were detained by a military patrol in southern Guayaquil.
According to Amnesty International, Ecuador’s Prosecutor’s Office has received reports of at least 43 possible cases of forced disappearance since 2023, the year Noboa took office pledging a tough stance against organized crime.
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