International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
U.S. sanctions cuban president Díaz-Canel over regime crackdown on protesters
The United States announced on Friday, for the first time, sanctions against Cuban President Miguel Díaz-Canel, citing his role in the regime’s crackdown on the Cuban people as the country marks four years since the historic anti-government protests of July 2021.
The U.S. State Department imposed visa restrictions on Díaz-Canel and other key figures in the Cuban government, including Defense Minister Álvaro López Miera and Interior Minister Lázaro Alberto Álvarez Casas, according to Senator Marco Rubio, who shared the update on social media platform X.
“The United States is capable of imposing migration sanctions on revolutionary leaders and maintaining a prolonged and ruthless economic war against Cuba, but it will not break the will of our people or its leaders,” responded Cuban Foreign Minister Bruno Rodríguez.
In addition, the State Department added “Torre K”, a newly inaugurated 42-story hotel in central Havana, to its list of restricted entities in an effort to prevent U.S. dollars from funding repression by the Cuban regime.
The hotel has sparked criticism for representing a massive state investment in luxury infrastructure despite Cuba’s declining tourism sector and worsening shortages of food, medicine, water, and electricity.
“While the Cuban people suffer from shortages of food, water, medicine, and electricity, the regime squanders money,” wrote Rubio.
In another post, Rubio also accused the Cuban government of torturing dissident José Daniel Ferrer and demanded immediate proof of life.
Ferrer, leader of the Patriotic Union of Cuba (Unpacu), was among the 553 prisoners released in January as part of an agreement between Cuba and the Vatican, following a decision by former U.S. President Joe Biden to temporarily remove Cuba from the State Sponsors of Terrorism list.
However, Ferrer’s conditional release was revoked in late April, prompting strong protests from Washington. The island has since been returned to the terrorism list after Republican President Donald Trump’s return to power in January.
International
Two missing after torrential rains cause flooding in Catalonia
Two people are missing in Catalonia, northeastern Spain, after torrential rains hit the region on Saturday night, causing flooding and disrupting rail traffic for several hours.
“We are working on the search for two people in Cubelles,” announced the Catalan Fire Department in a message posted on social media platform X. Cubelles is a town of about 17,000 residents located 50 kilometers from Barcelona.
Emergency crews remain active in the affected area, where the heavy rains overwhelmed local infrastructure and forced temporary closures of several transport routes.
International
Trump administration begins downsizing ‘bloated’ state department workforce
The U.S. Department of State issued layoff notices on Friday to more than 1,300 employees both domestically and abroad, marking the start of a workforce reduction aimed at trimming what officials have called a “bloated” staff. The move is part of President Donald Trump’s broader effort to restructure the federal government.
According to local media reports, more than 1,100 Civil Service employees and around 250 Foreign Service officers received notifications via email. Those affected will be placed on administrative leave for periods ranging from 90 to 120 days from the date of their dismissal notice.
The job cuts are part of a plan to centralize and streamline the agency’s operations without disrupting its overall functioning. The restructuring was designed by Secretary of State Marco Rubio, who had previously informed Congress in May of his intention to reduce the department’s workforce by 15%. The State Department currently employs about 18,000 people.
According to the top U.S. diplomat, the goal is to optimize what he described as a “bloated bureaucracy that stifles innovation and misallocates scarce resources,” as well as to eliminate remnants of “radical political ideology.”
The reorganization is expected to hit hardest in offices focused on human rights and refugee issues, which will now be handled by regional bureaus, according to The New York Times.
“We inherited a system that needed reform, and we are delivering it,” said State Department spokesperson Tammy Bruce on Thursday, adding that the Administration is committed to a foreign policy that puts U.S. interests first.
U.S. sanctions cuban president Díaz-Canel over regime crackdown on protesters
Two missing after torrential rains cause flooding in Catalonia
Trump administration begins downsizing ‘bloated’ state department workforce
Tec de Monterrey honors one of its students for his contribution to nanotechnology in medicine
Defense Minister commends salvadoran soldier for Central American Cross Country victory
Extension of the state of emergency approved in southern Chile
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