International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
Mexico City prepares for 13 million pilgrims at Basilica of Guadalupe
The Mexico City government is expecting at least 13 million pilgrims to visit the Basilica of Our Lady of Guadalupe for the December 12 celebrations honoring Mexico’s patron saint. To ensure the safety and care of visitors, authorities have launched the “Basilica Operation,” mobilizing more than 105,000 public servants.
Mayor Clara Brugada stated that the operation began on December 5 and will continue until December 14, covering the peak of visits to the basilica, located in the Gustavo A. Madero borough in the north of the city.
Key measures include reinforcement of the Metro public transport system, particularly at stations near the sanctuary, the installation of three helipads for medical emergencies, and the involvement of Civil Protection brigades, health ministry personnel, and public safety officers.
Secretary of Public Security Pablo Vázquez explained that the deployment also includes 255 patrol units and numerous specialized teams to manage crowds, traffic, and emergency situations, aiming to guarantee a secure experience for all pilgrims.
Central America
Mexico and Guatemala launch joint security operation after Agua Zarca border attack
The Government of Mexico announced on Tuesday that it has strengthened coordination with Guatemala following an armed confrontation in the community of Agua Zarca, in Guatemala’s Huehuetenango department, where a soldier was wounded in an attack attributed to organized-crime groups operating on both sides of the border.
The Secretary of Security and Citizen Protection, Omar García Harfuch, confirmed that Mexico is exchanging information with Guatemalan authorities and that Mexican Army units have been deployed along the border to reinforce surveillance and assist in reconnaissance operations.
The attack, Guatemala’s Defense Ministry stated, reflects the “criminal dynamics” dominating that border region, where different groups compete for drug and arms trafficking routes.
According to Guatemala’s Defense Ministry, the clash left a soldier wounded in the leg after suspected criminals crossed from Mexico and opened fire. The wounded soldier is reportedly in stable condition. Authorities also seized high-caliber weapons, explosives, tactical gear and drones, which were handed over for forensic analysis.
Mexican Defense Secretary General Ricardo Trevilla Trejo announced that a coordinated plan of operations will be launched involving both Mexican and Guatemalan forces along the border to counter these criminal networks.
Harfuch emphasized that the violence is not isolated but symptomatic of the ongoing struggle between criminal organizations for territorial control, and reiterated Mexico’s commitment to bilateral security cooperation and its intention to strengthen institutional presence in vulnerable border zones.
International
Zelensky meets Pope Leo XIV as review of U.S. peace plan continues
Ukrainian President Volodymyr Zelensky met on Tuesday with Pope Leo XIV in Italy, after pledging to deliver a response to the United States regarding the proposed peace plan aimed at ending the war with Russia.
The meeting with the pontiff took place at the papal residence in Castel Gandolfo, near Rome, where Leo XIV “reiterated the need to continue dialogue and renewed his urgent hope that the ongoing diplomatic initiatives may lead to a just and lasting peace,” the Vatican said in a statement.
His visit to Italy follows Monday’s meetings with European leaders in London and Brussels, amid pressure from U.S. President Donald Trump to agree to a peace plan that Zelensky said he is still reviewing.
According to Zelensky, the plan presented by Washington—originally consisting of 28 points—was reduced to 20 after discussions between Ukrainian and U.S. representatives over the weekend. “We are going to work on those 20 points. We are not completely satisfied with the proposals from our partners,” Zelensky said during an online press conference on Monday.
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