International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
79-Year-Old ICE Detainee Faces Hearing as Family Warns His Health Is Rapidly Deteriorating
Paul John Bojerski, a 79-year-old man detained by U.S. Immigration and Customs Enforcement (ICE) in Florida, will face a hearing before an immigration judge on Tuesday as his family warns that his health has sharply deteriorated due to detention conditions.
Bojerski was arrested on October 30 during a mandatory ICE appointment in Orlando. Although he has lived in the United States for more than seven decades, he never obtained U.S. citizenship. Born in a refugee camp in Germany after World War II, he legally immigrated with his family in 1952 at the age of five and has lived since then in the city of Sanford.
According to the Orlando Sentinel, his record includes criminal convictions from the 1960s and 1970s, which led to a deportation order that authorities did not carry out at the time.
In July, ICE warned him that he had to leave the country voluntarily. He was instructed to return on October 30 with a travel plan, but was unable to do so because he has no passport and no country willing to receive him. As a result, he was arrested and transported for eight hours to the detention center known as “Alligator Alcatraz,” located in the middle of the Everglades west of Miami.
Immigrant rights organizations have denounced “inhumane” conditions at that facility, which opened in July, reporting issues such as spoiled food, lack of medical care, limited access to drinking water, mosquito infestations, and difficulty contacting the outside world.
His family says Bojerski has lost mobility since being detained. He previously walked unassisted, but now uses a wheelchair, has been left without his usual treatment for chronic back problems, and reportedly fell to the floor of his cell without receiving help for hours.
He is currently being held at the Krome detention center in Miami, where a judge will determine on Tuesday whether he can be released on bond.
International
Trump: “I Don’t Rule Out Anything” When Asked About Troops for Venezuela
U.S. President Donald Trump said Monday that he may speak at some point with Venezuelan President Nicolás Maduro and did not rule out the possibility of sending American troops to the South American nation.
Trump’s remarks come amid heightened tensions over the U.S. military deployment in the Caribbean aimed at combating drug trafficking. Venezuela views the operation as a step toward toppling Maduro, whom Washington accuses of leading a “terrorist” organization involved in narcotics trafficking.
“At some point, I will talk to him,” Trump told reporters in the Oval Office. Maduro “has not been good for the United States,” he added.
When asked whether he ruled out sending U.S. troops to Venezuela, Trump replied, “No, I don’t rule it out. I don’t rule out anything.”
“We have to take care of Venezuela,” he continued. “They have sent hundreds of thousands of people from their prisons into our country.”
International
Armed Civilians Block Roads in Michoacán Amid Operation Targeting Criminal Leader
Armed civilians blocked several highways in the western Mexican state of Michoacán on Monday in response to a security operation targeting a criminal leader, just a week after President Claudia Sheinbaum’s government reinforced the presence of federal forces in the region.
The federal deployment was increased following the early November shooting death of Carlos Manzo, mayor of the municipality of Uruapan. His killing sparked protests and widespread demands for justice.
Michoacán is home to major drug trafficking groups such as the powerful Jalisco New Generation Cartel (CJNG) and La Nueva Familia Michoacana—both designated as “foreign terrorist organizations” by U.S. President Donald Trump in February.
“Following an operation to apprehend a priority target (a criminal leader), armed civilians set up roadblocks and burned vehicles at various highway points in La Piedad, Zamora, and Pátzcuaro,” the Michoacán Public Security Secretariat reported on X.
“Our Civil Guard is already clearing the roads; two suspected individuals were killed,” the agency added, without specifying the intended target of the operation.
Organized crime groups in Mexico frequently block roads to prevent the capture of their leaders or to hinder law enforcement activities.
The blockades also occurred just hours before a new state public security secretary took office. José Antonio Cruz—a former official of the local prosecutor’s office and former National Guard executive—assumed the position, replacing Juan Carlos Oseguera.
The killing of Mayor Manzo during a public Day of the Dead event on November 1 triggered protests throughout Michoacán. During demonstrations held Saturday in Mexico City, participants also demanded justice for the crime.
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