International

Cancer drug cooperation could save 1.5 mn lives a year: researchers

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AFP

Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.

The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.

Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.

More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.

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The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.

Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.

The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.

Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.

That represents roughly 1.5 million of the around 10 million people who die of cancer every year.

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‘Challenging’ for doctors

“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.

Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.

The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.

But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.

The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.

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“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.

International

Bill Gates to testify before Congress over Epstein connections

Bill Gates is set to testify on June 10 before a congressional committee in United States investigating links connected to the late sex offender Jeffrey Epstein, a source familiar with the matter told AFP on Tuesday.

The Microsoft co-founder is among several high-profile figures named in documents released by the Department of Justice, which detail alleged close associations, questionable financial dealings, and private photographs involving Epstein.

According to a spokesperson cited by Politico, Gates “welcomes” the opportunity to appear before the committee. The representative emphasized that Gates “never attended or participated in any illegal activities with Epstein” and is prepared to answer questions to support the investigation.

The Bill & Melinda Gates Foundation did not immediately respond to AFP’s request for comment.

In late February, Gates told members of his foundation’s board that his association with Epstein was a “huge mistake.” He has consistently denied any involvement in the financier’s criminal activities. Epstein died by suicide in prison in 2019 while awaiting trial on charges of sex trafficking minors.

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“I did nothing illegal. I saw nothing illegal,” Gates said, according to a recording obtained by The Wall Street Journal.

Gates acknowledged that his relationship with Epstein began in 2011, three years after Epstein pleaded guilty to soliciting prostitution from a minor.

A draft email written by Epstein and released by the Department of Justice referenced alleged extramarital relationships involving Gates. The message, which was apparently never sent, claimed that Epstein had helped “Bill” obtain medication related to encounters with Russian women.

Gates admitted to having had two extramarital affairs but denied any involvement with Epstein’s victims.

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International

Former Trump allies call for removal, cite 25th Amendment amid Iran threats

Former allies of U.S. President Donald Trump on Tuesday called for his removal from office, arguing he is unfit to continue in the role following recent threats to “wipe out an entire civilization,” made just hours before the deadline of his ultimatum to Iran.

One of the most prominent voices was former Republican congresswoman Marjorie Taylor Greene, who invoked the 25th Amendment of the U.S. Constitution as a mechanism to remove the president from power.

“25th Amendment! Not a single bomb has fallen on the U.S. We cannot annihilate an entire civilization. This is evil and insanity,” Greene wrote on social media platform X.

Greene, once a leading figure within Trump’s political movement during his first term, broke with the president last November over disagreements on foreign policy and his handling of controversial cases.

Another former supporter, controversial commentator Alex Jones, also raised the possibility of applying the constitutional provision during his show, in a conversation with attorney Robert Barnes.

Barnes explained that invoking the 25th Amendment requires the support of two-thirds of Congress, making it a more complex process than impeachment.

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Section 4 of the amendment, ratified in 1967, establishes that the vice president, together with a majority of the cabinet, can declare the president unable to perform the duties of the office, a decision that must then be confirmed by both chambers of Congress.

The statements come amid rising international tensions and increasing domestic political pressure on the president.

International

Trump pauses strikes on Iran, extends ultimatum by two weeks

The president of the United States, Donald Trump, announced a temporary suspension of attacks against Iran for a period of two weeks, extending the ultimatum he had imposed on Tehran just hours before its deadline.

According to the president, the measure is conditional on Iran allowing the “full, immediate, and secure” reopening of the Strait of Hormuz. Trump stated that the decision would involve a reciprocal ceasefire between both parties.

The announcement was made through a message on his social media platform, where he emphasized that the pause in military actions is intended to create space for de-escalation in the region.

He also noted that the decision followed a conversation with the prime minister of Pakistan, Shehbaz Sharif, who requested a two-week extension of the ultimatum.

The move comes amid heightened global tensions, marked by escalating threats and concerns over the potential impact of the conflict on key international energy trade routes.