International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
Ukraine declares nationwide energy emergency amid russian attacks and extreme cold
The Ukrainian government on Wednesday declared a nationwide energy state of emergency amid continued Russian military attacks and extreme winter weather, with nighttime temperatures dropping as low as minus 18 degrees Celsius.
“The consequences of Russian attacks and worsening weather conditions are severe (…) Overall, a state of emergency will be declared for Ukraine’s energy sector,” Ukrainian President Volodymyr Zelensky said in a statement posted on social media following a meeting with senior officials.
Zelensky announced the creation of a “permanent coordination headquarters” to manage the crisis in the capital, Kyiv, and tasked former defence minister and current energy chief Denys Shmyhal with overseeing support efforts for affected individuals and communities, including addressing power outages, heating shortages and other “practical issues.”
“There are many problems that require urgent solutions,” the president said, noting that repair crews, energy companies, municipal services and the State Emergency Service are working “around the clock” to restore electricity supplies. Kyiv has been particularly affected after Russian strikes last Friday disabled key parts of the power grid, as daytime temperatures hover around minus 12 degrees Celsius and plunge to minus 18 at night.
Zelensky added that public authorities will “maximize efforts with partners to obtain the necessary equipment and additional support,” while the government will ensure “maximum deregulation of all processes” to speed up the connection of backup power equipment to the grid. He also confirmed that work is underway to significantly increase electricity imports into Ukraine.
The Ukrainian leader further instructed his Cabinet to review curfew regulations in light of the extreme cold, arguing that citizens must have the greatest possible access to assistance centers, while businesses should be given flexibility to plan their operations according to the state of the energy system.
International
France joins Denmark’s ‘Operation Arctic Resistance’ in Greenland amid U.S. tensions
French President Emmanuel Macron confirmed in the early hours of Thursday (Wednesday afternoon in El Salvador) that France will take part in “Operation Arctic Resistance,” after Denmark announced it would expand its military presence in Greenland amid rising tensions with the United States over Washington’s stated ambitions regarding the semi-autonomous territory.
“At Denmark’s request, I have decided that France will participate in the joint exercises organized by Denmark in Greenland, ‘Operation Arctic Resistance,’” Macron said in a brief message posted on social media at 5:18 p.m.
The French president added that “the first French military elements are already on their way, with others to follow,” though he did not specify the number of troops being deployed or the scale of France’s planned contribution.
The governments of Sweden, Norway and Germany have also confirmed the deployment of military contingents to Greenland. Germany’s armed forces will send a 13-member reconnaissance team to the Greenlandic capital, Nuuk, to take part in a mission scheduled to run from Thursday through Saturday, according to the German Ministry of Defence.
Denmark’s announcement came shortly before a Danish delegation met at the White House with U.S. Vice President JD Vance and Secretary of State Marco Rubio to discuss Washington’s plans regarding Greenland. Copenhagen said the military activities would be carried out “in close cooperation with NATO allies.”
International
Iran closes airspace amid U.S. threats and deadly nationwide protests
Iranian authorities closed the country’s airspace in the early hours of Thursday, according to data from flight-tracking website FlightRadar24, amid growing threats of a possible U.S. attack as protests across the country continue and have reportedly left thousands dead.
According to FlightRadar24, the Iranian government suspended all flights to and from the country, except for international flights that have received special authorization. The notice was initially issued for a duration of just over two hours.
The move comes after U.S. President Donald Trump in recent days threatened to strike Iran if its security forces failed to halt the deaths linked to weeks-long protests that began in Tehran and later spread to other Iranian cities. Despite the threats, the White House said diplomacy remains Trump’s preferred option.
Speaking from the Oval Office on Wednesday, Trump claimed that “the deaths in Iran have stopped” and said there would be no executions of protesters following his warnings to Tehran. He added that his administration would seek to verify those claims.
“I’ve been told the deaths in Iran are stopping. They’ve stopped, and that there are no plans for executions,” Trump told reporters, cautioning that the United States would be “very upset” if those assurances proved to be untrue.
The statements contrast with reports from rights groups. The Norway-based NGO Iran Human Rights (IHRNGO) said on Wednesday that more than 3,400 people have been killed since the protests erupted. Meanwhile, Kurdish-Iranian rights group Hengaw reported this week that a 26-year-old Iranian man, Erfan Soltani, was facing execution as of Wednesday.
Ukraine declares nationwide energy emergency amid russian attacks and extreme cold
France joins Denmark’s ‘Operation Arctic Resistance’ in Greenland amid U.S. tensions
Iran closes airspace amid U.S. threats and deadly nationwide protests
Tec de Monterrey honors one of its students for his contribution to nanotechnology in medicine
Defense Minister commends salvadoran soldier for Central American Cross Country victory
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