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Cancer drug cooperation could save 1.5 mn lives a year: researchers

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AFP

Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.

The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.

Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.

More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.

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The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.

Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.

The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.

Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent. 

That represents roughly 1.5 million of the around 10 million people who die of cancer every year.

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‘Challenging’ for doctors

“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.

Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients. 

The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.

But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress. 

The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.

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“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement. 

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International

Salvadoran National Arrested in New Jersey with Over 70 Machine Gun Conversion Devices

The U.S. Department of Justice announced the arrest of 21-year-old Salvadoran national Erick Márquez Cruz after authorities allegedly discovered more than 70 machine gun conversion devices and other firearm-related components during a search of his residence in North Bergen, New Jersey.

According to the Justice Department, law enforcement officers executed a search warrant on June 25 at Cruz’s home, where they recovered a 3D printer that was allegedly being used to manufacture firearm components. Investigators also seized 17 3D-printed firearm frames, magazines, and more than 70 machine gun conversion devices (MCDs).

Federal authorities explained that the conversion devices, which are classified as machine guns under U.S. law, are designed to convert semiautomatic firearms into fully automatic weapons capable of firing multiple rounds with a single pull of the trigger.

Cruz has been charged with unlawful possession of a machine gun. If convicted, he faces a maximum sentence of 10 years in federal prison and a fine of up to $250,000, or twice the gross financial gain resulting from the offense, whichever is greater.

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International

Venezuela Earthquakes Spark Diplomatic Thaw With Former Critics

The devastating earthquakes that struck Venezuela have triggered an unprecedented diplomatic thaw between Caracas and several governments that had maintained strained relations with the country, raising hopes that the humanitarian response could pave the way for broader international engagement under the administration of U.S. President Donald Trump.

The United States, Chile, Argentina, El Salvador and Israel were among the first countries to announce humanitarian assistance, deploy search-and-rescue teams or establish direct contact with acting President Delcy Rodríguez to coordinate relief efforts in the hardest-hit areas.

Canada also joined the international response by announcing humanitarian aid while opening a domestic debate over the importance of maintaining diplomatic representation in countries such as Venezuela to better respond to emergencies and assist its citizens abroad.

The wave of international cooperation marks a sharp contrast to the diplomatic tensions that followed Venezuela’s disputed presidential election on July 28, 2024, in which Nicolás Maduro was declared the winner.

In the aftermath of that vote, the governments of Argentina, Chile, Costa Rica, Panama, Peru, the Dominican Republic and Uruguay publicly questioned the official election results, triggering one of the region’s most significant diplomatic crises in recent years.

The Venezuelan government responded by withdrawing its diplomatic personnel from several of those countries and demanding the departure of their representatives, further deepening the country’s international isolation.

The humanitarian emergency created by the twin earthquakes has now prompted renewed communication between Caracas and governments that had previously suspended or significantly reduced diplomatic engagement, underscoring how major natural disasters can temporarily reshape international relations despite longstanding political disagreements.

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International

Venezuela Earthquake Death Toll Surpasses 1,700 as Search for Survivors Continues

Venezuelan authorities have raised the death toll from last week’s twin earthquakes to more than 1,700, as rescue teams continue searching for survivors in the country’s hardest-hit coastal region.

According to the latest official report released on Sunday, the powerful earthquakes, measuring magnitudes 7.2 and 7.5, have claimed at least 1,719 lives. National Assembly President Jorge Rodríguez also reported that 5,034 people were injured, while 15,866 have been displaced and another 22,619 are receiving medical care.

The United Nations has expressed growing concern over the scale of the disaster, estimating that as many as 68,000 people could still be missing.

La Guaira bears the brunt of the disaster

The coastal state of La Guaira has suffered the greatest loss of life and the most extensive damage. The Venezuelan government has declared the area a disaster zone and placed it under military control as emergency operations continue.

Five days after the earthquakes struck, search-and-rescue teams remain on the ground, supported by additional heavy equipment and international rescue crews. However, hopes of finding more survivors beneath the rubble continue to diminish with each passing day.

One of the most dramatic rescue operations unfolded Monday in Catia La Mar, where emergency teams from El Salvador, Mexico, and Venezuela worked together to reach a 21-year-old man who has remained trapped inside a collapsed building since the earthquakes struck.

The twin earthquakes hit Venezuela on June 24, with the epicenter located between San Felipe and Yumare in the country’s northern region. The first quake, measuring magnitude 7.2, struck at 6:04 p.m. local time. Just 39 seconds later, a second and stronger magnitude 7.5 earthquake occurred farther to the southeast. Combined, the seismic activity lasted nearly three minutes, causing widespread devastation across several regions of the country.

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