International

Cancer drug cooperation could save 1.5 mn lives a year: researchers

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AFP

Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.

The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.

Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.

More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.

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The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.

Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.

The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.

Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.

That represents roughly 1.5 million of the around 10 million people who die of cancer every year.

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‘Challenging’ for doctors

“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.

Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.

The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.

But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.

The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.

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“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.

International

Fire at substation triggers major blackout in San Francisco

The U.S. city of San Francisco was plunged into darkness Saturday night after a power outage left about 130,000 customers without electricity, although the utility company said service was restored to most users within hours.

Pacific Gas & Electric Company (PG&E) said in a statement posted on X that nearly 90,000 homes had their power restored by 9:00 p.m. local time (05:00 GMT on Sunday), while the remaining 40,000 customers were expected to have service restored overnight.

Large areas of the city, a major technology hub with a population of around 800,000, were affected by the blackout, which disrupted public transportation and left traffic lights out of service during the busy weekend before Christmas, a crucial period for retail businesses.

“I know it’s been a difficult day,” San Francisco Mayor Daniel Lurie said in a video posted on social media from the city’s emergency operations center. “There has been progress, but for those still without power, we want to make sure they are safe and checking in on their neighbors,” he added.

Lurie said police officers and firefighters advised residents to stay home as much as possible. He also noted that officers and traffic inspectors were deployed to manage intersections where traffic lights were not functioning.

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The mayor confirmed that the outage was caused by a fire at an electrical substation. Parts of the city were also covered in fog, further complicating conditions during the incident.

As a result of the blackout, many businesses were forced to close despite it being the weekend before Christmas. The sudden drop in shopper traffic ahead of the holiday is “devastating” for retailers, the manager of home goods store Black & Gold told the San Francisco Chronicle.

International

Cristina Kirchner recovering after appendicitis surgery in Buenos Aires

Former Argentine President Cristina Kirchner underwent surgery on Saturday after being diagnosed with appendicitis and is recovering “without complications,” according to a medical report released by the Otamendi Sanatorium.

Kirchner was admitted to the Buenos Aires medical center on Saturday after experiencing abdominal pain. Doctors performed a laparoscopic procedure that confirmed a diagnosis of “appendicitis with localized peritonitis,” the statement said, adding that her post-operative recovery has been progressing without complications.

The former president was transferred to the clinic with judicial authorization from her apartment in Buenos Aires, where she is serving a six-year sentence under house arrest for corruption.

International

Argentina detects first local cases of Influenza A (H3N2) Subclade K

Argentina’s National Administration of Laboratories and Health Institutes (ANLIS) “Dr. Carlos G. Malbrán” has confirmed the detection of three cases of influenza A (H3N2) corresponding to subclade K in the country. These are the first locally recorded cases of this variant, which has become predominant in several countries in the Northern Hemisphere in recent months and is associated with higher transmissibility.

The cases were identified through the National Network of Laboratories and Sentinel Units and confirmed by the National Reference Laboratory of INEI-ANLIS using genomic sequencing techniques. According to health authorities, the cases involve two adolescents from the province of Santa Cruz, detected as part of the Ambulatory Monitoring Strategy for Acute Respiratory Infections, and a child who had been hospitalized in the Autonomous City of Buenos Aires.

In all three cases, patients experienced mild illness and recovered without complications. Officials did not specify whether any of the affected individuals had a recent travel history.

The jurisdictions involved have already launched the corresponding epidemiological investigations and are responsible for ensuring timely medical care for the detected cases. According to the latest integrated surveillance report, the circulation of influenza and other respiratory viruses in Argentina remains within expected levels for this time of year.