International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
At Least Eight Dead and 19 Injured in Deadly Bus Crash in Veracruz, Mexico
A tragic bus accident in the eastern state of Veracruz left at least eight people dead and 19 others injured on Wednesday afternoon, according to local authorities.
The vehicle was traveling through the town of Zontecomatlán when it crashed near a ravine, state Civil Protection officials reported late Wednesday night. “Regrettably, the prosecutor’s office has confirmed eight fatalities,” the agency stated in an official release.
Emergency Response and Medical Care Rescue teams worked into the night to assist the survivors. The 19 injured passengers were stabilized at the scene before being transported to hospitals in the nearby municipalities of Chicontepec and Huayacocotla. While the identities of the victims have not yet been released, Mexican press reports indicate the bus was en route from Mexico City to Chicontepec.
A Recurring Issue on Mexican Highways Road accidents involving long-haul passenger buses and freight transport are a frequent occurrence in Mexico. Experts often cite excessive speed, mechanical failure, or driver fatigue as the primary catalysts for these tragedies.
This latest incident follows another major disaster in late November, where 10 people were killed and 20 injured in a similar bus crash in the western state of Michoacán. The recurring nature of these accidents continues to spark national debate regarding the enforcement of stricter safety regulations for commercial transport units.
International
Jair Bolsonaro Hospitalized for Inguinal Hernia Surgery While Serving Sentence for Attempted Coup
Former Brazilian President Jair Bolsonaro, currently serving a 27-year prison sentence for an attempted coup, underwent surgery this Thursday for an inguinal hernia. The procedure took place at the DF Star Hospital in Brasilia, according to his wife, Michelle Bolsonaro.
The 70-year-old former leader left prison on Wednesday for the first time since his incarceration in late November to prepare for the operation. “My love has just gone to the surgical center,” Michelle Bolsonaro posted on Instagram, where she has been documenting her accompaniment during his hospitalization.
Surgical Expectations and Health History Medical professionals treating the far-right ex-president (2019-2022) anticipate the operation will last approximately four hours. His recovery period in the hospital is expected to extend between five and seven days.
Dr. Claudio Birolini explained on Wednesday that while the surgery is standardized, it remains complex due to the patient’s history. Bolsonaro continues to suffer from the long-term effects of a 2018 campaign rally stabbing, an injury that required several major abdominal surgeries in the years following the attack.
“There is no such thing as a simple surgery. However, this is a scheduled and standardized procedure, so we expect it to be carried out without major complications,” Dr. Birolini stated.
Potential Additional Procedures Following the hernia repair, the medical team will evaluate whether Bolsonaro can undergo a second procedure: an anesthetic block of the phrenic nerve. This nerve controls the diaphragm, and the intervention would aim to resolve a chronic case of recurrent hiccups that has plagued the former president for years.
Bolsonaro remains under heavy security at the medical facility as he serves his lengthy sentence related to the events surrounding the January 2023 institutional crisis in Brazil.
International
Trump Orders Construction of New ‘Golden Fleet’ to Revitalize U.S. Naval Superiority
President Donald Trump issued an executive order this Monday for the immediate construction of two new warships that will bear his name. These vessels will be the pioneers of what he described as the “Golden Fleet,” a future generation of “Trump-class” battleships that he claimed would be “100 times more powerful” than those currently in service.
The announcement took place at his private residence in Mar-a-Lago, Florida. The President indicated that following the initial two ships, the administration aims to commission up to 25 additional vessels. He is scheduled to meet with Florida-based contractors next week to expedite production, criticizing existing defense firms for failing to deliver results efficiently.
This naval expansion is a cornerstone of Trump’s goal to revitalized the American shipbuilding industry and address the strategic gap between the U.S. and competitors like China.
The move comes amid heightened geopolitical tension. Just last week, Trump ordered the seizure of all sanctioned tankers involved with Venezuela’s “ghost fleet” to cripple the country’s crude oil industry. Since December 10, the U.S. military—deployed in the Caribbean under the guise of counter-narcotics operations—has already detained two tankers linked to Venezuelan oil transport.
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