International

Cancer drug cooperation could save 1.5 mn lives a year: researchers

Ilustrative image

AFP

Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.

The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.

Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.

More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.

20250501_mh_noexigencia_dui_728x90

The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.

Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.

The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.

Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.

That represents roughly 1.5 million of the around 10 million people who die of cancer every year.

20250501_mh_noexigencia_dui_728x90

‘Challenging’ for doctors

“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.

Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.

The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.

But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.

The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.

20250501_mh_noexigencia_dui_728x90

“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.

International

Epstein Denies Being ‘the Devil’ in Newly Released Video Interview

Jeffrey Epstein claims he was the least dangerous type of sex offender and denied being “the devil” in a video interview included in the latest batch of documents released over the weekend by the U.S. Department of Justice.

The roughly two-hour interview was conducted by Steve Bannon, a former adviser to U.S. President Donald Trump, and appears to have been recorded at the late financier’s New York residence on an unknown date.

Epstein died by suicide in 2019 while in jail awaiting trial on sex trafficking charges involving minors. Since December, the U.S. government has released millions of documents related to the case under transparency laws.

“Do you think you’re the devil incarnate?” Bannon asks Epstein in the video interview revealed in the latest release.

“No, but I do have a good mirror,” Epstein replies with a smile, wearing a black shirt and glasses. When pressed again, he adds, “I don’t know. Why would you say that?”

20250501_mh_noexigencia_dui_728x90

Epstein, who pleaded guilty in 2008 to soliciting a minor for prostitution, also appears to downplay the seriousness of his conviction.

He objects when Bannon refers to him as a “Level Three sexual predator,” a classification in the United States indicating a very serious threat to public safety.

“No, I’m the lowest,” Epstein says.

“But still an offender,” Bannon responds.

“Yes,” Epstein replies.

20250501_mh_noexigencia_dui_728x90

The exchange comes after Bannon asks Epstein whether he considers his wealth to be “dirty,” suggesting it was earned by advising “the worst people in the world.”

Epstein insists that he made his money legally, while acknowledging that “ethics is always a complicated issue.”

He claims he donated money to help eradicate polio in Pakistan and India, apparently in an attempt to justify the origins of his fortune.

The documents also show that Bannon maintained regular correspondence with Epstein, who offered to help the far-right political figure spread his conservative ideology in Europe.

Since Trump took office in January 2025, U.S. authorities have released millions of pages related to Epstein, along with photos and videos.

20250501_mh_noexigencia_dui_728x90

These materials have shed new light on Epstein’s ties to high-profile business executives such as Microsoft co-founder Bill Gates, celebrities including filmmaker Woody Allen, and academics and political figures, among them Trump and former President Bill Clinton.

International

Hypothermia Linked to Most Deaths During New York’s Recent Cold Spell

Hypothermia “played a role” in 13 of the 16 deaths recorded in New York City during the recent period of extreme cold, Mayor Mandami said at a press conference. Three of the deaths were classified as drug overdoses.

None of the individuals were sleeping on the streets at the time of their deaths, the mayor added, noting that some had previously been in contact with emergency shelter services.

Mandami said the city has activated emergency warming centers and deployed a fleet of 20 vehicles staffed with medical personnel to respond to the cold weather crisis.

“As of this morning, we have made more than 930 referrals to shelters and safe facilities. We have also involuntarily transported 18 New Yorkers who were deemed a danger to themselves or others,” he said.

According to official statistics, New York City recorded between nine and 27 cold-related deaths per year from 2005 to 2021. That number rose to 34 in 2021 and climbed further to 54 in 2022.

20250501_mh_noexigencia_dui_728x90

City Comptroller Mark Levine estimated that there are “tens of thousands” of homeless New Yorkers, “most of them families with children.”

He said that “nearly 95%” of the city’s homeless population lives in municipal shelters.

In August 2021, those shelters housed 44,586 people, the “lowest daily population in nearly a decade,” according to official data.

However, the shelter population increased from 22,955 to 62,679 people between January 2000 and January 2020, highlighting the long-term growth of homelessness in the city.

20250501_mh_noexigencia_dui_728x90

International

NFL Investigating Emails Linking Giants Executive to Jeffrey Epstein

NFL Commissioner Roger Goodell said on Monday that the league will “examine all the facts” regarding contacts between New York Giants co-owner Steve Tisch and Jeffrey Epstein, revealed in documents recently released about the late convicted sex offender.

The batch of files, made public on Friday by the U.S. Department of Justice, includes emails suggesting that Epstein introduced several women to Tisch.

Tisch, a film producer who has never been charged in connection with Epstein, issued a statement last week denying any wrongdoing.

“I had a brief relationship in which we exchanged emails about adult women, and we also discussed film, philanthropy, and investments,” Tisch said of his correspondence with Epstein, which dates back to 2013.

“I did not accept any of his invitations and never went to his island. As we all now know, he was a terrible person and someone I deeply regret having associated with,” he added.

20250501_mh_noexigencia_dui_728x90

Speaking at a press conference in San Jose, California, on Monday, Goodell said the NFL would carefully review the details of the ties between Tisch and Epstein.

“We’re going to examine all the facts,” the commissioner said. “We’re going to look at the context of those exchanges, try to understand them, and see how that fits within the league’s policies.”

Tisch, 76, could face disciplinary action under the NFL’s strict personal conduct policy, even if he is not found guilty of a crime.

“We’re going to take this step by step. First, let’s gather all the facts,” Goodell said at the press conference, which was part of the events leading up to Sunday’s Super Bowl between the Seattle Seahawks and the New England Patriots.