International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
Authorities Say Teotihuacán Gunman Was Obsessed With Mass Shootings and Extremist Symbolism
Julio César Jasso Ramírez, identified by authorities as the gunman behind the armed attack at the archaeological site of Teotihuacán, had allegedly spent years building a personal narrative shaped by an obsession with historical mass shootings, extremist symbolism, and an increasing detachment from reality.
According to preliminary findings from the Fiscalía General de Justicia del Estado de México, the 27-year-old suspect, originally from the southern Mexican state of Oaxaca, acted alone and appeared to have carefully planned the attack.
Investigators also pointed to signs of a severe psychological or psychiatric disorder. One official involved in the case stated that the suspect seemed to live in “his own reality,” disconnected from the world around him.
“I would not speak of a motive; I would speak of psychopathy, a condition, an illness,” the official said while discussing the ongoing investigation.
Authorities reported that Jasso Ramírez was allegedly fixated on mass violence incidents that occurred outside Mexico, particularly in the United States.
Among the items found in his possession were writings, images, and materials reportedly linked to the Columbine High School massacre, the school shooting that took place on April 20, 1999.
The investigation remains ongoing as authorities continue analyzing evidence connected to the suspect’s background and mental state.
International
Iran refuses to reopen strait of Hormuz amid ongoing U.S. Naval blockade
Iran reaffirmed on Wednesday that it will not reopen the Strait of Hormuz while the United States maintains its naval blockade against Iranian ports and vessels, amid rising geopolitical tensions in the region.
Iranian Parliament Speaker Mohamad Baqer Qalibaf warned that reopening the crucial maritime route depends on Washington honoring the ceasefire agreement. According to Qalibaf, Iran considers the deal to be violated due to ongoing U.S. actions.
The Iranian official accused the United States of carrying out a “naval blockade and the hijacking of the global economy,” while also pointing to Israeli military operations in Lebanon as part of the broader conflict affecting the region.
Qalibaf stated that military and economic pressure would not force Iran to change its position. “The United States and Israel failed to achieve their goals through military aggression, and they will not succeed through intimidation. The only path forward is to recognize the rights of the Iranian nation,” he said.
His remarks come amid stalled negotiations between Iran and the United States following direct talks held on April 11 and 12 in Islamabad.
The discussions, led by U.S. Vice President JD Vance and Iranian representatives, have shown little progress in recent days, increasing uncertainty over whether dialogue between the two sides will resume.
U.S. President Donald Trump recently announced an extension of the ceasefire but decided to keep the naval blockade in place, a move Tehran considers incompatible with ongoing negotiations.
Meanwhile, Iran’s Islamic Revolutionary Guard Corps intensified operations in the area by seizing two vessels in the Strait of Hormuz, accusing them of operating without the required permits and escorting them into Iranian territory.
The Strait of Hormuz remains one of the world’s most critical oil trade routes, and any prolonged disruption could have significant consequences for global energy markets.
International
Maradona’s daughter accuses medical team of “horrible manipulation” in court
One of the daughters of Diego Maradona testified in court this Tuesday, breaking down in tears as she denounced what she described as “absolute and horrible manipulation” by her father’s medical team, during an emotional hearing in Argentina.
Gianinna Maradona stated that she and her siblings agreed to home hospitalization after doctors presented it as the best option following the neurosurgery Maradona underwent on November 3, 2020.
The football icon died on November 25 of that year, and the ongoing trial seeks to determine whether the conditions of his home care were appropriate.
According to Gianinna, what the family found at the residence where Maradona was recovering did not match what had been promised. She testified that there was no adequate medical equipment, constant monitoring, or even an ambulance available, despite assurances of continuous care.
“The manipulation was absolute and horrible,” she said during the hearing in San Isidro, near Buenos Aires.
She accused members of the medical team, including neurosurgeon Leopoldo Luque, psychiatrist Agustina Cosachov, and psychologist Carlos Díaz, of misleading the family.
“I trusted these people, and all they did was manipulate us and leave my son without a grandfather,” she added.
Later in her testimony, recalling that six years have passed since her father’s death, she became emotional and said she struggled deeply with grief in the aftermath.
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