International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
U.S. Sanctions Network Linked to Fentanyl Trafficking Across India, Guatemala and Mexico
The United States Department of State announced sanctions on Thursday against 23 individuals and companies allegedly linked to an international fentanyl production and smuggling network operating in India, Guatemala and Mexico.
According to the State Department, the network supplied precursor chemicals to the Sinaloa Cartel, which the United States has designated as a Foreign Terrorist Organization.
Washington declared fentanyl, a powerful synthetic opioid, a weapon of mass destruction last year due to its role in the ongoing overdose crisis in the United States.
“By targeting the entire supply chain — from chemical suppliers in Asia to logistical intermediaries in Central America and cartel-linked networks in Mexico — the Trump Administration is dismantling networks that destabilize governance across our hemisphere and threaten U.S. security,” the State Department said.
In a separate statement, the Office of Foreign Assets Control detailed sanctions against three Indian chemical and pharmaceutical companies: Sutaria, Agrat and SR Chemicals, along with a sales executive accused of supplying precursor chemicals to contacts in Guatemala and Mexico.
In Guatemala, authorities sanctioned J and C Import and Central Logística de Servicios, as well as intermediary Jaime Augusto Barrientos.
The OFAC also designated several intermediaries and import companies operating in the Mexican state of Sinaloa.
As part of the investigation, U.S. authorities identified Ramiro Baltazar Félix as a member of Los Mayos, a faction of the Sinaloa Cartel, and Alejandro Reynoso, accused of operating clandestine drug laboratories in Guadalajara.
International
Pope Leo XIV Says Countries Have Border Rights but Migrants Deserve Respect
Pope Leo XIV said Thursday that migrants must be treated with dignity as he addressed the global migration crisis during a press conference aboard the plane returning from his tour of Africa.
The pontiff answered questions from journalists regarding his upcoming trip to Spain, which will include a visit to the Canary Islands, a region heavily affected by migration flows and growing political polarization surrounding the issue.
“Obviously, migration is a very complex issue and affects many countries — not only Spain, not only Europe, but also the United States. It is a global phenomenon,” the pope said.
Pope Leo XIV also questioned the role of developed nations in addressing the crisis.
“My response begins with a question: What is the Global North doing to help the Global South and those countries where young people no longer see a future and dream of going north, even when the North sometimes has no answers to offer?” he asked.
While acknowledging that “a state has the right to establish rules for its borders,” the pope insisted that the debate must go beyond border control and address the structural causes that force people to leave their home countries.
International
Authorities Say Teotihuacán Gunman Was Obsessed With Mass Shootings and Extremist Symbolism
Julio César Jasso Ramírez, identified by authorities as the gunman behind the armed attack at the archaeological site of Teotihuacán, had allegedly spent years building a personal narrative shaped by an obsession with historical mass shootings, extremist symbolism, and an increasing detachment from reality.
According to preliminary findings from the Fiscalía General de Justicia del Estado de México, the 27-year-old suspect, originally from the southern Mexican state of Oaxaca, acted alone and appeared to have carefully planned the attack.
Investigators also pointed to signs of a severe psychological or psychiatric disorder. One official involved in the case stated that the suspect seemed to live in “his own reality,” disconnected from the world around him.
“I would not speak of a motive; I would speak of psychopathy, a condition, an illness,” the official said while discussing the ongoing investigation.
Authorities reported that Jasso Ramírez was allegedly fixated on mass violence incidents that occurred outside Mexico, particularly in the United States.
Among the items found in his possession were writings, images, and materials reportedly linked to the Columbine High School massacre, the school shooting that took place on April 20, 1999.
The investigation remains ongoing as authorities continue analyzing evidence connected to the suspect’s background and mental state.
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