International

Cancer drug cooperation could save 1.5 mn lives a year: researchers

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AFP

Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.

The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.

Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.

More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.

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The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.

Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.

The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.

Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.

That represents roughly 1.5 million of the around 10 million people who die of cancer every year.

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‘Challenging’ for doctors

“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.

Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.

The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.

But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.

The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.

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“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.

International

Brazil offers to mediate Colombia-Ecuador tensions, calls for restraint

The government of Brazil has offered to mediate in the ongoing tensions between Colombia and Ecuador, while calling on both nations to exercise restraint.

In a statement released Wednesday, Brazil’s Ministry of Foreign Affairs urged the parties involved to act with moderation and seek a peaceful resolution to the dispute.

“Brazil encourages all sides to act with moderation in order to find a peaceful solution to the controversy. It stands ready to support dialogue efforts aimed at preserving peace and security in the region,” the statement said.

Brazil also expressed “serious concern” over reports of deaths in the border area between Colombia and Ecuador, noting that the circumstances surrounding the incidents have not yet been clarified.

The diplomatic move comes amid rising tensions between the neighboring countries, increasing regional concern over stability and security along their shared border.

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International

U.S. lowers travel advisory for much of Venezuela but keeps high-risk zones under warning

The U.S. Department of State announced on Thursday that it has lowered its travel advisory for much of Venezuela to Level 3 (“Reconsider Travel”), reflecting what it described as improved security conditions in parts of the country.

However, the agency will maintain the highest Level 4 warning (“Do Not Travel”) for several regions, including the states of Táchira, Amazonas, Apure, Aragua and Guárico, as well as rural areas of Bolívar, citing ongoing risks such as crime, kidnapping and terrorism.

The updated advisory marks a shift from December, when the United States raised the alert for Venezuela to Level 4 nationwide, warning of severe security threats.

Despite the partial downgrade, U.S. authorities continue to urge caution, emphasizing that conditions remain volatile in certain areas and that travelers should carefully assess risks before planning any trips to the country.

International

EU lawmakers move to ban AI tools that generate non-consensual nude images

Members of the European Parliament are pushing to ban across the bloc artificial intelligence services that allow users to digitally “undress” people without their consent.

The proposal, adopted on Wednesday at committee level, aims to prohibit applications that generate non-consensual explicit images. Irish lawmaker Michael McNamara, one of the sponsors, said the measure seeks to stop tools that “have caused significant harm for the benefit of a few.”

Dutch MEP Kim van Sparrentak welcomed the move, calling it “a major victory, especially for women and children in Europe.”

The amendment, part of broader EU legislation on artificial intelligence, was approved by the Parliament’s civil liberties and internal market committees. It specifically targets systems that use AI to create or manipulate sexually explicit or intimate images resembling identifiable individuals without their consent.

The proposal will be put to a full vote in the European Parliament on March 26. If adopted, lawmakers and European Union member states will need to agree on a final version before it can take effect.

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Separately, representatives of the 27 EU countries recently backed a Franco-Spanish amendment seeking to ban AI services used to generate non-consensual sexual images or child sexual abuse material.

The initiative follows controversy surrounding a feature introduced in Grok, developed by xAI, which allowed users to create simulated nude images from real photos. The tool sparked widespread criticism and prompted an EU investigation.

In response, xAI restricted image generation features in mid-January to paying subscribers and stated it blocks the creation of sexualized images in jurisdictions where such content is illegal.