International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
El Chapo’s son Joaquín Guzmán López pleads guilty to U.S. drug trafficking charges
Joaquín Guzmán López, one of the sons of notorious Mexican drug lord Joaquín “El Chapo” Guzmán, pleaded guilty on Monday to drug trafficking charges in a U.S. court, months after his brother Ovidio reached a similar plea agreement, according to local media reports.
The defendant appeared before a federal court in Chicago early Monday afternoon and changed his previous plea in the case, the Chicago Tribune reported. U.S. authorities accuse him of forming, together with his three brothers, the cartel faction known as “Los Chapitos.”
The group is believed to have continued the operations of El Chapo, who has been serving a life sentence in the United States since 2019.
Guzmán López, 39, was arrested after landing in Texas in a small aircraft alongside cartel co-founder Ismael “El Mayo” Zambada.
International
Venezuela authorizes return flights as U.S. continues deportations amid rising tensions
The arrival of U.S. aircraft carrying undocumented Venezuelan migrants continued regularly despite rising tensions between Washington and Caracas over President Donald Trump’s military deployment in the Caribbean.
Trump maintains that the deployment is part of an anti-narcotics operation, while Venezuelan President Nicolás Maduro insists the true objective is to remove him from power and seize the nation’s oil resources.
Venezuela’s aviation authority has “received a request from the United States government to resume repatriation flights for Venezuelan migrants from that country to Venezuela,” the Ministry of Transportation said in a statement .
“Under the instructions of President Nicolás Maduro, authorization has been granted for these aircraft to enter our airspace,” it added.
Caracas will permit two Eastern Airlines flights to land on Wednesday and Friday.
Migration remains one of the Trump administration’s flagship issues. On Monday, the U.S. president held a meeting with his National Security Council to discuss the situation in Venezuela, a day after confirming he had spoken with Maduro by phone, without offering further details.
According to the Venezuelan government, roughly 75 deportation flights have been carried out this year, returning at least 13,956 Venezuelans from the United States.
International
20,000 rounds stolen from german army after driver leaves cargo unattended
The German army confirmed the theft of a shipment of ammunition that occurred a week ago while it was being transported by a civilian delivery driver, a military spokesperson told AFP, confirming earlier media reports.
According to Der Spiegel and the regional broadcaster MDR, around 20,000 rounds of ammunition were stolen from an unguarded parking lot near Magdeburg, in eastern Germany, while the driver was asleep in a nearby hotel. No information has been released regarding the identity of the suspects, and the military declined to specify the exact type or amount of ammunition taken.
Authorities have also not indicated how the perpetrators knew the cargo would be left unattended.
“The theft was discovered upon delivery at the barracks,” the German army spokesperson said.
A police spokeswoman confirmed to AFP that an investigation has been opened but refused to provide further details “for tactical reasons.”
Sources close to the German military, cited by Der Spiegel, believe it is unlikely the theft was a coincidence. They suspect the thieves waited for the driver to stop for the night before striking.
Der Spiegel also reported that the Defense Ministry normally requires two drivers for this type of transport to ensure the cargo is constantly monitored. However, in this case only one driver was assigned, meaning the civilian transport company failed to comply with the security protocols.
El Chapo’s son Joaquín Guzmán López pleads guilty to U.S. drug trafficking charges
Venezuela authorizes return flights as U.S. continues deportations amid rising tensions
20,000 rounds stolen from german army after driver leaves cargo unattended
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