International
Cancer drug cooperation could save 1.5 mn lives a year: researchers
AFP
Around 1.5 million lives could be saved every year if the world worked together to more swiftly approve new cancer drugs, researchers said Tuesday.
The figure was based on how long it took two recent cancer drugs to be approved across the world after they were given the green light by the United States.
Pembrolizumab, an effective treatment for most lung cancers, was approved by the US Food and Drug Administration (FDA) in 2016.
More than 600,000 years of patients’ lives could have been saved if Brazil, Canada, China, India, Japan and the European Union had approved the drug at the same time, according to an analysis published in the Harvard Business Review, which is not peer-reviewed.
The authors, including US oncologist Bobby Daly, also looked at enzalutamide, which is used to treat prostate cancer.
Enzalutamide was approved by the FDA in 2012, but was not authorised in China for another seven years, partly due to a requirement for separate trials to be carried out there.
The analysis by members of the Bloomberg New Economy International Cancer Coalition found that 284,000 years of patient lives could have been saved if other countries had approved the drug alongside the FDA.
Extrapolating out from their findings, the researchers estimated that if each of the approximately seven cancer drugs approved by the FDA a year were authorised worldwide, it would reduce the number of cancer-related deaths by 10-20 percent.
That represents roughly 1.5 million of the around 10 million people who die of cancer every year.
‘Challenging’ for doctors
“In China alone an estimated 500,000 patient life-years could be saved through harmonisation of trial requirements that have delayed patient access to treatment,” former Australian prime minister Kevin Rudd, co-chair of the Bloomberg cancer coalition, said in a statement.
Mary Gospodarowicz, also a member of the coalition, said that it was “challenging” as an oncologist in Canada when a drug was approved in the US but would take years to be able to prescribe it to her patients.
The study assumed that the rest of the world had the infrastructure to diagnose and treat cancer as well as the US, which is not always the case, Gospodarowicz told AFP via phone from the World Cancer Congress in Geneva on Tuesday.
But it served as an example of how “removing the barriers to drug approval would be beneficial to patients around the world,” said the former president of the Union for International Cancer Control, which is holding the congress.
The authors of the analysis called on countries to embrace Project Orbis, a US-led framework aiming to get cancer drugs trialled and approved at the same time in multiple countries.
“The US has already made significant progress in setting up the regulatory infrastructure for cancer treatment with the Project Orbis initiative and the task ahead is to take that framework and internationalise it,” former New York mayor Michael Bloomberg said in a statement.
International
Venezuela accuses U.S. of using Naval Deployment to pressure Maduro government
The world’s largest aircraft carrier, the USS Gerald R. Ford, joined the U.S. Navy’s anti-drug operation in Latin America on Tuesday—a deployment Venezuela has condemned as an attempt to pressure President Nicolás Maduro from power.
In a statement, the U.S. Southern Command confirmed that the carrier, ordered to deploy nearly three weeks ago, has entered its area of responsibility, which includes Latin America and the Caribbean.
“The world’s largest aircraft carrier will strengthen the United States’ ability to detect, monitor, and dismantle illicit actors and activities that threaten the security and prosperity of U.S. territory and our safety in the Western Hemisphere,” said Pentagon spokesperson Sean Parnell.
According to the White House, the U.S. government under Donald Trump has carried out about twenty operations in the Caribbean and the Pacific since early September, resulting in the deaths of 76 suspected drug traffickers.
However, U.S. authorities have not yet presented evidence that the targeted vessels were being used for drug trafficking or posed a direct threat to the country.
The operations have raised concerns in Caracas, where the Maduro administration views the deployment as a strategic move aimed at provoking regime change in Venezuela.
International
Venezuela mobilizes forces nationwide as tensions with U.S. rise
Venezuela’s armed forces launched a “massive” nationwide deployment on Tuesday in response to what the government calls “imperialist threats” from the United States, which continues its anti-drug military operation in the region and is preparing for the arrival of its most advanced aircraft carrier.
Since late August, U.S. forces have maintained a growing presence in the Caribbean to combat alleged drug trafficking originating from Colombia and Venezuela. The operation has resulted in the bombing of 20 vessels in international waters in the Caribbean and Pacific, leaving 76 people dead.
Venezuelan authorities claim the U.S. mission is aimed at toppling President Nicolás Maduro. While insisting he seeks peace, Maduro has repeatedly warned the country is prepared to defend itself and has frequently showcased military activities.
A statement from Venezuela’s Defense Ministry said the deployment includes land, air, naval, river and missile systems; armed forces units; the Bolivarian militia; and additional police, military and civilian defense structures.
State broadcaster VTV aired speeches from military leaders in various states, along with images of troops mobilizing and equipment being positioned.
However, analysts note that these frequent and highly publicized announcements do not always lead to visible operations on the ground.
On Monday, Maduro cautioned that Venezuela has the “strength and power” to respond to any aggression, including mobilizing civilians. “If imperialism were to strike and do harm, from the moment the order is given, the entire Venezuelan people would mobilize and fight,” he warned.
International
Jara: “Real toughness” means targeting drug money in Chile’s crime fight
Left-wing presidential candidate Jeannette Jara said during Chile’s final debate on Monday that the “real tough approach” to crime is to go after the financial networks behind drug trafficking and organized crime.
Rising crime, often linked in public discourse to a surge in irregular migration, has become the top concern among Chileans and has dominated the election campaign.
Although Chile’s homicide rate has nearly tripled over the past decade — from 2.5 to 6.7 per 100,000 inhabitants — the country remains one of the safest in Latin America, according to the United Nations.
“I want to call on the right-wing candidates to join us in targeting those who control the money behind drug trafficking and organized crime. That is real tough action,” Jara, who is favored to win Sunday’s first-round vote, declared during the debate.
All eight candidates faced off on Monday night in the final televised confrontation before the election.
Polls — unavailable since they were suspended on November 2 — indicate that far-right candidate José Antonio Kast is likely to finish second behind Jara, but would hold the advantage in a potential December 14 runoff.
Kast is expected to consolidate support from three other right-wing contenders: Evelyn Matthei, Johannes Kaiser and Franco Parisi.
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