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Moderna, Merck see positive results from skin cancer vaccine

| By AFP |

The Moderna and Merck drug makers on Tuesday announced positive results from a trial in which messenger RNA technology was used for the first time to make personalized vaccines for skin cancer patients.

The mRNA technology proved vital in the development of vaccines against Covid-19, and scientists have long believed it could help fight other viruses and diseases like cancer.

In a preliminary trial, 150 people who had had their melanoma tumor surgically removed were given up to nine doses of the experimental vaccine alongside the skin cancer treatment Keytruda.

The study showed a 44 percent reduction in risk of death or relapse compared to patients who were only treated with Keytruda, an immunotherapy medicine.

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“Today’s results are highly encouraging for the field of cancer treatment,” Moderna’s Chief Executive Officer Stephane Bancel, said in a statement.

“mRNA has been transformative for COVID-19, and now, for the first time ever, we have demonstrated the potential for mRNA to have an impact on outcomes in a randomized clinical trial in melanoma.”

Moderna and Merck, known as MSD outside of North America, will soon publish the full results of the study, the results of which have not yet been peer-reviewed. The companies will also launch a Phase 3 trial in 2023, which involves a larger number of patients.

Messenger RNA is a molecule within cells that carries instructions to form proteins. Scientists can design them to make a particular protein in the body that can help fight viruses and other illnesses.

Moderna and drugmaker Pfizer-BioNTech were the first to use the technology to create the mRNA vaccines used to fight Covid-19.

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The melanoma vaccine is tailor-made to “prime the immune system so that a patient can generate a tailored antitumor response specific to their tumor mutation signature,” said Moderna’s statement.

Melanoma is the worst form of skin cancer, and nearly 325,000 new cases were diagnosed in 2020. Some 8,000 people are expected to die from melanoma in 2022, said the statement.

Moderna and Merck agreed in October to jointly develop the personalized skin cancer vaccine, for which they will share costs and profits.

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International

Austrian man arrested in Croatia with deceased woman as passenger in his car

A 65-year-old Austrian citizen was arrested at a border checkpoint in Croatia after attempting to enter the country in his car with a deceased woman sitting as a passenger, police announced on Tuesday.

The man was detained in a routine check in late November in Gunja, a border area separating Bosnia from Croatia, the police told AFP. Suspicious because they saw “no consciousness or movement” from the passenger, Croatian officers called a doctor, who confirmed the death of the 83-year-old woman, also Austrian, according to her identification.

The woman’s relationship to the suspect is unknown. She had died in Bosnia, and the man intended to repatriate her body to Austria to “avoid the formalities related to transporting a corpse,” according to the police. Croatian media reported that the man was her legal guardian.

Once her death was confirmed, a funeral service took charge of the body.

 

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International

Colombian nationals arrested for human trafficking and disappearance of migrant boat

 

Colombian authorities arrested two nationals accused of the illegal trafficking of migrants to the United States and of endangering lives due to the disappearance of a boat with 40 people aboard, U.S. Department of Justice officials reported on Tuesday.

Hernando Manuel de la Cruz Rivera Orjuela, 52, and Luis Enrique Linero Pinto, 40, both Colombian citizens, were arrested on December 13 in Colombia at the request of the United States for their alleged involvement in a “transnational human trafficking operation,” the department said in a statement.

According to the charges, the detainees were transporting migrants to San Andrés Island in the Caribbean, where they would then be taken by boat to Nicaragua. The goal was to reach the United States through Central America and Mexico.

The accused are said to have advised the migrants on how to reach San Andrés Island, where they personally received them, arranged accommodations, and “took them to the boats that transported them to Nicaragua so they could enter the United States illegally,” the statement reads.

“These defendants put several migrants on the boat that disappeared off the coast of Nicaragua in 2023,” said Deputy Attorney General Nicole M. Argentieri, head of the U.S. Department of Justice’s Criminal Division, as cited in the statement.

Both men are “directly and personally responsible for the illicit trafficking of migrants on that vessel,” according to the indictment dated October 23.

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International

Homemade landmine explosion in Michoacán kills two soldiers, injures five

Two soldiers were killed and five others were injured by the explosion of homemade landmines planted by a criminal group in a mountainous area of the Mexican state of Michoacán (west), the Secretary of Defense reported on Tuesday.

The attack occurred on Monday morning in the municipality of Cotija, a border area between Michoacán and the state of Jalisco, when the military was conducting a reconnaissance mission after receiving information about an armed camp in the area, explained Secretary General Ricardo Trevilla.

“At that moment, an improvised explosive device detonated. Unfortunately, two soldiers lost their lives, and five others were injured,” the military leader detailed. The affected soldiers were airlifted to hospitals in the region by a military helicopter, while the rest of the team continued with the reconnaissance of the area.

Trevilla stated that before the explosion, the military unit had located the dismembered bodies of three people, and upon continuing the mission, they confirmed the camp was abandoned.

Asked about the individuals responsible for placing the explosives, the general suggested they could be criminals linked to the local group Cárteles Unidos, which operates in Michoacán and uses these tactics in their territorial dispute with the Jalisco New Generation Cartel, one of the most powerful criminal organizations in the country.

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