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Moderna reduces production of COVID-19 vaccine

Moderna reduces production of COVID-19 vaccine

September 13 |

Drugmaker Moderna announced Wednesday that it is scaling back manufacturing of its COVID-19 vaccine, an updated version of which was approved this week by U.S. regulators.

Moderna said the decision is driven by lower post-pandemic demand that will help the company reach its target of 75% to 80% gross revenue growth sooner.

Moderna is in talks with its partners that fill vials and syringes with its messenger RNA-based COVID vaccines globally to reduce production, Stephen Hoge, president of the Massachusetts-based company, said in an interview.

The reduction, Hoge added, will help Moderna adapt to the endemic phase of the disease, which had led to a drop in demand for COVID vaccines as buyers have reduced orders for injections.

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Moderna predicted in August that U.S. demand for the vaccine would reach between 50 million and 100 million doses in the fall season. About 153.8 million COVID injections were administered in the U.S. in 2022, according to the Centers for Disease Control and Prevention.

“For the last two years, we’ve been in pandemic mode producing 1 billion doses a year,” Hoge said. “We’ve been waiting for the time when the pandemic is officially behind us and we need to restructure that manufacturing footprint.”

Following clearance from the U.S. Food and Drug Administration (FDA) on Monday, Moderna said it would begin shipping doses of the COVID vaccine throughout the United States.

The company has agreements to supply its vaccine to other countries, including Britain, Canada and Japan, but does not yet have an agreement with the European Union, according to Hoge, who also said COVID was the focus of Moderna’s manufacturing agreement with China.

Hoge added that while Moderna is urgently working to reduce COVID manufacturing, talks with third-party manufacturers, which will help produce the upcoming respiratory syncytial virus (RSV) and influenza vaccines that investors hope will begin to replace Moderna’s dwindling COVID revenues, could extend into next year.

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“These are relationships we will need for decades to come,” Hoge said.

Moderna also announced Wednesday that it had completed the regulatory filing for its RSV vaccine and that its flu vaccine had generated a stronger immune response against all four A and B strains of the virus compared with traditional flu vaccines in a late-stage trial.

The efficacy of Moderna’s flu vaccine was demonstrated in all age groups, including older patients, and proved to be safe and tolerable, according to the company.

Moderna also said it had found its vaccine to be equal or superior to Sanofi’s high-dose flu vaccine in a separate initial comparative study.

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International

Pope Francis meets former Gaza hostages

Pope Francis met on Thursday at the Vatican with 16 Israelis who had been held hostage in Gaza for months by the Islamist group Hamas, according to the official Vatican news website.

The group consisted of ten women, four men, and two children, as reported by the same source. Several of the former hostages showed the Argentine pontiff banners or photos of their loved ones who remain in captivity.

Francis had previously met with the families of hostages in April this year and November 2023, but this was the first time he had met with individuals who had personally endured captivity.

Since the conflict between Israel and Hamas began, the pope has repeatedly called for the immediate release of Israeli hostages, while also condemning the suffering of the Palestinian population.

The war erupted on October 7, 2023, when Islamist militants attacked southern Israel, killing 1,206 people, mostly civilians, and kidnapping 251, according to an AFP tally based on official Israeli figures that include hostages who died in captivity.

Of the kidnapped, 97 are still being held in Gaza, but the Israeli military estimates that 34 of them have died.

The military offensive launched by Israel in response has killed at least 43,736 people in the Gaza Strip, mostly civilians, according to data from the Ministry of Health in the Hamas-governed territory.

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International

Israeli airstrikes on Damascus kill 15 and injure 16, including women and children

Israeli forces carried out airstrikes on residential buildings in the Syrian capital, Damascus, and its surroundings on Thursday, resulting in at least 15 deaths and 16 injuries, according to Syria’s Ministry of Defense and state television.

The ministry stated that around 3:20 p.m. local time (12:20 GMT), the Israeli military launched an aerial attack from the direction of the occupied Golan Heights, targeting several residential buildings in the Mazzeh neighborhood in western Damascus and the Qudsaya suburb to the northwest of the capital.

The airstrikes “resulted in the death of 15 people and injuries to 16 others, including women and children,” based on initial estimates, in addition to significant damage to private property and civilian buildings, the ministry added.

Meanwhile, state television reported Israeli airstrikes on three buildings in Mazzeh and another on a building in an educational complex located in a residential area of Qudsaya.

Following the strikes, loud explosions were heard throughout the city, and thick plumes of smoke could be seen rising from the targeted locations. Ambulances and emergency services rushed to the scene to attend to the victims.

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International

Drug trafficker dies after boat collision with Guardia Civil Vessel in Sanlúca

Three people were on the boat that collided with a Guardia Civil vessel around midnight at the mouth of the Guadalquivir River in Sanlúcar de Barrameda, near the Andalusian city of Cádiz, a spokesperson for the Civil Guard reported.

Two officers sustained “contusions,” the spokesperson explained.

The drug traffickers managed to bring the boat to shore, where one of them was “abandoned” severely injured. The other two fled.

The Civil Guard officers attempted to resuscitate the victim before transporting him to Sanlúcar de Barrameda, but he ultimately died early in the morning.

The other two suspects took advantage of the officers’ absence while they were taking the victim and returned to set their boat on fire.

The collision occurred very close to the site of another accident on September 1, where a drug trafficker died following a Guardia Civil pursuit.

The suspects’ boat traveled “400 meters” before crashing head-on and “at full speed” into the riverbank, where a hundred bundles of hashish were found.

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